Curcacycline A — a novel cyclic octapeptide isolated from the latex of <i>Jatropha curcas</i> L

Berg, A. J. J. van den; Horsten, S. F. A. J.; Bosch, J. J. Kettenes‐van den; Kroes, B. H.; Beukelman, C.J.; Leeflang, Bas R.; Labadie, R. P.

doi:10.1016/0014-5793(94)01405-p

Cited by 101 publications

(53 citation statements)

References 18 publications

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“…A novel cyclic octapeptide (GlyLeu-Leu-GlyThr-Val-Leu-Leu-Gly), curcacycline, has also been isolated from jatropha latex. This cyclic octapeptide has been shown to inhibit classical pathway activity of human complement, and proliferation of human T-cells (Van den Berg et al, 1995).…”

Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

372

214

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Livestock and aquaculture production is under political and social pressure, especially in the European Union (EU), to decrease pollution and environmental damage arising due to animal agriculture. The EU has banned the use of antibiotics and other chemicals, which have been shown to be effective in promoting growth and reducing environment pollutants because of the risk caused to humans by chemical residues in food and by antibiotic resistance being passed on to human pathogens. As a result of this, scientists have intensified efforts in exploiting plants, plant extracts or natural plant compounds as potential natural alternatives for enhancing the livestock productivity. This paper discusses work on the effects of various phytochemicals and plant secondary metabolites in ruminant and fish species. The focus is on (i) plants such as Ananas comosus (pine apple), Momordica charantia (bitter gourd) and Azadirachta indica (neem) containing anthelmintic compounds and for their use for controlling internal parasites; (ii) plants containing polyphenols and their applications for protecting proteins from degradation in the rumen, increasing efficiency of microbial protein synthesis in rumen and decreasing methane emission; for using as antioxidants, antibacterial and antihelmintic agents; and for changing meat colour and for increasing n-3 fatty acids and conjugated linoleic acid in meat; (iii) saponin-rich plants such as quillaja, yucca and Sapindus saponaria for increasing the efficiency of rumen fermentation, decreasing methane emission and enhancing growth; for producing desired nutritional attributes such as lowering of cholesterol in monogastric animals; for increasing growth of fish (common carp and Nile tilapia) and for changing male to female ratio in tilapia; and for use as molluscicidal agents; (iv) Moringa oleifera leaves as a source of plant growth factor(s), antioxidants, beta-carotene, vitamin C, and various glucosinolates and their degraded products for possible use as antibacterial, antioxidant, anticarcinogenic and antipest agents; (v) Jatropha curcas toxic variety with high levels of various phytochemicals such as trypsin inhibitor, lectin, phytate and phorbol esters in seeds limiting the use of seed meal in fish and livestock diets; and the use of phorbol esters as bio-pesticidal agent; and (vi) lesser-known legumes such as Entada phaseoloides seeds containing high levels of trypsin inhibitor and saponins, Sesbania aculeate seeds rich in non-starch polysaccharides and Mucuna pruriens var. utilis seeds rich in L-3,4-dihydroxyphenylalanine and their potential as fish feed; Cassia fistula seeds as a source of antioxidants; and the use of Canavalia ensiformis, C. gladiata and C. virosa seeds containing high levels of trypsin inhinitor, lectins and canavanine. The paper also presents some challenges and future areas of work in this field.

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Section: Plants Containing Multibioactive Compoundsmentioning

confidence: 99%

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Makkar

Francis

Becker

2007

Animal

372

214

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“…Structural elucidation of these peptide molecules has helped with better comprehension of the activities of these molecules [79,80]. Reports on in situ synthesis (live plant) of MNPs are scanty.…”

Section: Asparagus Racemosusmentioning

confidence: 99%

Biological synthesis of metallic nanoparticles: plants, animals and microbial aspects

Das

Pachapur

Lonappan

et al. 2017

Nanotechnol. Environ. Eng.

375

138

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The green synthesis (GS) of different metallic nanoparticles (MNPs) has re-evaluated plants, animals and microorganisms for their natural potential to reduce metallic ions into neutral atoms at no expense of toxic and hazardous chemicals. Contrary to chemically synthesized MNPs, GS offers advantages of enhanced biocompatibility and thus has better scope for biomedical applications. Plant, animals and microorganisms belonging to lower and higher taxonomic groups have been experimented for GS of MNPs, such as gold (Au), silver (Ag), copper oxide (CuO), zinc oxide (ZnO), iron (Fe 2 O 3 ), palladium (Pd), platinum (Pt), nickel oxide (NiO) and magnesium oxide (MgO). Among the different plant groups used for GS, angiosperms and algae have been explored the most with great success. GS with animal-derived biomaterials, such as chitin, silk (sericin, fibroin and spider silk) or cell extract of invertebrates have also been reported. Gram positive and gram negative bacteria, different fungal species and virus particles have also shown their abilities in the reduction of metal ions. However, not a thumb rule, most of the reducing agents sourced from living world also act as capping agents and render MNPs less toxic or more biocompatible. The most unexplored area so far in GS is the mechanism studies for different natural reducing agents expect for few of them, such as tea and neem plants. This review encompasses the recent advances in the GS of MNPs using plants, animals and microorganisms and analyzes the key points and further discusses the pros and cons of GS in respect of chemical synthesis.

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“…J. curcas has served globally as a source of lamp oil and soap, and also as a medicinal plant for the treatment of dropsy, paralysis, rheumatism, and certain skin diseases for a long time (Jiangsu New Medicinal College, 1977). Previous investigations on the secondary metabolites of J. curcas had resulted in the isolation of diterpenoids (Naengchomnong et al, 1994(Naengchomnong et al, , 1986Ravindranath et al, 2003Ravindranath et al, , 2004Chianese et al, 2011;Wang et al, 2009;Liu et al, 2012), sesquiterpenoids (Wang et al, 2008), flavonoids (Khafagy et al, 1977;Subramanian et al, 1971), lignans (Li et al, 2010), coumarins (Kong et al, 1996;Mitra et al, 1970;Matsuse et al, 1999) and cyclic peptides (Van den Berg et al, 1995;Auvin et al, 1997) with various biological activities. In order to isolate the minor active compounds, we investigated this plant and obtained three new diterpenoids along with nine known ones from the CHCl 3 extract of the root bark.…”

Section: Introductionmentioning

confidence: 99%

Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

Zhang

Zhao

et al. 2012

Phytochemistry Letters

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Curcacycline A — a novel cyclic octapeptide isolated from the latex of Jatropha curcas L

Cited by 101 publications

References 18 publications

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Bioactivity of phytochemicals in some lesser-known plants and their effects and potential applications in livestock and aquaculture production systems

Biological synthesis of metallic nanoparticles: plants, animals and microbial aspects

Diterpenoids from the root bark of Jatropha curcas and their cytotoxic activities

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