Objective: Otapiapia is a locally produced, easily accessible, non-regulated household pesticide, which could easily contaminate human food. The ameliorative effect of ethanol leaf extract of Moringa oliefera on otapiapiainduced changes in oxidative stress, lipid profile and atherogenic indices of albino rats was investigated using standard methods.Methodology: Twenty-four apparently healthy Wister male albino rats (150-180 g) were divided into 4 groups (I-IV) of 6 animals each. Group I served as the control, while group II animals were given otapiapia contaminated feed and distilled water. Group III were fed uncontaminated diet and M. oleifera extract drink. Group IV animals were also given the contaminated diet and M. oliefera extract. The feed and drinks were provided ad libitum for a period of 14 days.
Result:The results show that intake of otapiapia significantly (p<0.05) reduced serum superoxide dismutase and catalase activities and HDL-c concentration but increased significantly (p<0.05) the concentrations of malondialdehyde, total cholesterol, triacylglycerol, LDL-c and VLDL-c. The derangements were significantly more pronounced in the atherogenic predictor indices than with lipid profile values. The observed effects of otapiapia were significantly (p<0.05) countered by administration of M. oliefera leaf extract.
Conclusion:The results indicate that M. oleifera is a potent anti-poison with ameliorative effect against otapiapia-induced changes in biomarkers of oxidative and atherogenic damages in animals.
This study aimed at investigating the changes in activities of dehydrogenase, catalase, alkaline phosphatase, acid phosphatase and alkaline protease of soil samples exposed to electromagnetic radiations (EMR) from mobile phone for the periods of 0, 30, 60 and 90 days. EMR-unexposed soil samples served as the source of control enzyme activities. The mean enzyme activities from the EMRexposed soil were significantly (p<0.05) lower than those from the unexposed samples. The overall percentage changes in enzymes activities of the EMR-unexposed and exposed soil samples for dehydrogenase, catalase, alkaline phosphatase, acid phosphatase and alkaline protease relative to their respective starting values were 124.42 and -65.15%, 138.01 and -13.87%, 94.09 and 19.70%, 101.01 and -41.00%, and 162.55 and -21.71% respectively. The results show that EMR from mobile phones elicited significant negative impact on soil enzymes activities.
Objective: Otapiapia is a locally produced, easily accessible, non-regulated household pesticide, which could easily contaminate human food. The ameliorative effect of ethanol leaf extract of Moringa oliefera on otapiapiainduced changes in oxidative stress, lipid profile and atherogenic indices of albino rats was investigated using standard methods.Methodology: Twenty-four apparently healthy Wister male albino rats (150-180 g) were divided into 4 groups (I-IV) of 6 animals each. Group I served as the control, while group II animals were given otapiapia contaminated feed and distilled water. Group III were fed uncontaminated diet and M. oleifera extract drink. Group IV animals were also given the contaminated diet and M. oliefera extract. The feed and drinks were provided ad libitum for a period of 14 days.
Result:The results show that intake of otapiapia significantly (p<0.05) reduced serum superoxide dismutase and catalase activities and HDL-c concentration but increased significantly (p<0.05) the concentrations of malondialdehyde, total cholesterol, triacylglycerol, LDL-c and VLDL-c. The derangements were significantly more pronounced in the atherogenic predictor indices than with lipid profile values. The observed effects of otapiapia were significantly (p<0.05) countered by administration of M. oliefera leaf extract.
Conclusion:The results indicate that M. oleifera is a potent anti-poison with ameliorative effect against otapiapia-induced changes in biomarkers of oxidative and atherogenic damages in animals.
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