19 patients showing the features of diffuse retinal pigment epitheliopathy, as described by Zweng and Little, were studied. Diffuse retinal pigment epitheliopathy resembles both pigment epithelial detachment and central serous choriopathy, but can be differentiated by the following characteristic features: widespread distribution of small pigment epithelial detachments, little or no leakage visible on the fluorescence angiogram, extensive pigmentary changes, chronic course with exacerbations and remissions, and fair visual prognosis.

Folding of the pigment epithelium and the choroid, although clearly visible in the fluogram, often cannot be visualized by ophthalmoscopy or by conventional photography, so that it can be said that fluography has disclosed this entity. Its occurrence has been described in deformation of the coats of the eye by a retrobulbar mass, hypermetropia, chronic retrobulbar inflammations, and choroidal tumours.In the present series, which contains material from five eye clinics, cases are demonstrated of choroidal folds in papilloedema caused by raised intracranial pressure, and in macular degeneration.These last cases have given rise to a hypothetical genesis of these folds, namely by the combination of retinal displacement and the presence of subretinal fluid.Fluorescein angiography of the fundus (fluography) can reveal structures which are difficult or impossible to set by other methods. A good example of this are the folds of the pigment epithelium and choroid to be described here. A number of such cases have been described recently (Table II).

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