A Fluorographic Study of Reticular Patterns in the Fundus

Winning, C.H.O.M. von; Oosterhuis, J. A.

doi:10.1016/0002-9394(74)90460-7

Cited by 6 publications

(5 citation statements)

References 7 publications

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“…They seem to represent actual spots of hyperpigmentation that are visible on colored imaging [ 5 , 62 , 63 ]. FAF may also demonstrate changes compatible with pattern dystrophy, as mentioned previously in the text [ 5 , 63 , 64 , 65 , 66 , 67 ] ( Figure 2 ).…”

Section: Narrative Review Findingssupporting

confidence: 62%

“…The frequency of such changes has been reported to vary between 10% and 70% [ 5 , 63 , 64 ]. According to a classification system suggested by Agarwal et al, these changes may be divided into vitelliform, butterfly, and reticular dystrophy, or fundus flavimaculatus or pulverulentus [ 5 , 63 , 64 , 65 , 66 , 67 ]. Some studies have suggested that the presence of these pattern dystrophy type changes might be a valuable and reliable prognostic factor regarding secondary CNV manifestation, but at the same time acknowledge that more longitudinal data are needed to further corroborate this hypothesis [ 5 , 63 ].…”

Section: Narrative Review Findingsmentioning

confidence: 99%

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Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch’s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using “PubMed”, “Web of Science”, “Scopus”, “ScienceDirect”, “Google Scholar”, “medRxiv”, and “bioRxiv.” Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget’s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.

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Section: Narrative Review Findingssupporting

confidence: 62%

Section: Narrative Review Findingsmentioning

confidence: 99%

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Tsokolas,

Tossounis,

Tyradellis

et al. 2024

Vision

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“…Based on a classification suggested by Agarwal and Gass, findings can be categorized due to their similarity to pattern dystrophies, into vitelliform, butterfly, and reticular dystrophy, or fundus flavimaculatus or pulverulentus (von Winning and Oosterhuis, 1974; Shiraki et al, 2001; Agarwal et al, 2005; Sawa et al, 2006; Finger et al, 2009a). It has been postulated that the presence of a pattern dystrophy is a prognostic sign for CNV development although further longitudinal data are needed for confirmation (Finger et al, 2009a).…”

Section: Funduscopic Findingsmentioning

confidence: 99%

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

Gliem¹,

Zaeytijd²,

Finger³

et al. 2013

Front. Genet.

121

206

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Pseudoxanthoma elasticum (PXE) is an inherited multi-system disorder characterized by ectopic mineralization and fragmentation of elastic fibers in the skin, the elastic laminae of blood vessels and Bruch’s membrane in the eye. Biallelic mutations in the ATP-binding cassette (ABC) transporter gene ABCC6 on chromosome 16 are responsible for the disease. The pathophysiology is incompletely understood. However, there is consent that a metabolic alteration leads to dysfunction in extracellular calcium homeostasis and subsequent calcification of connective tissues rich in elastic fibers. This review summarizes and aims at explaining the variety of phenotypic ocular findings in patients with PXE. Specialized imaging techniques including white light fundus photography, blue light autofluorescence, near-infrared confocal reflectance imaging, high resolution optical coherence tomography, fluorescein and indocyanine green (ICG) angiography have revealed characteristic lesions at the ocular fundus of PXE patients. These include the classic signs of angioid streaks, peau d’orange, comet lesions, and choroidal neovascularizations (CNVs), but also the more recently recognized features such as chorioretinal atrophy, subretinal fluid independent from CNV, pattern dystrophy-like changes, debris accumulation under the retinal pigment epithelium, reticular drusen and a decreased fluorescence on late phase ICG angiography.

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“…The basis for the heightened sensitivity of angiography in revealing changes in the RPE was discussed by von Winning and Oosterhuis (1974). Ophthalmoscopy and color photographs may suggest an almost normal fundus.…”

Section: Multifocal and Recurrent Choroidopathy Syndromementioning

confidence: 99%

Multifocal and recurrent (serous) choroidopathy (MARC) syndrome: A new variety of idiopathic central serous choroidopathy

Frederick

1984

Doc Ophthalmol

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Presented is a group of 110 patients with patches of granular atrophy of the retinal pigment epithelium which I believe represents a new subtype of idiopathic central serous choroidopathy (ICSC). It is designated as multifocal and recurrent (serous) choroidopathy (MARC) syndrome. Such patients are the 'older' ICSC patients and they usually have bilateral involvement which may show marked asymmetry. The history is seldom helpful in defining previous episodes of leaking. The fundus changes are thought to represent the sequelae of multiple, recurrent, or chronic choroidopathy in the form of serous detachments of the retinal pigment epithelium and/or neurosensory retina. Such detachments may not be present at the time of a single examination, and thus the fundus picture may be puzzling without an awareness of this syndrome which exhibits a wide spectrum of severity. Difficulties in detecting the low detachments and fluorescein leaking are emphasized. There is often a marked disparity between the ophthalmoscopic and the fluorescein angiographic pictures, and examination by the latter technique is urged. I do not believe this entity progresses to senile disciform disease, but can result in marked visual loss. If extrafoveal leaking is found in the presence of decreased acuity and a macular detachment, and if there is evidence of previous attacks, photocoagulation can effectively flatten the retina. I believe photocoagulation therapy under these conditions is justifiable.

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A Fluorographic Study of Reticular Patterns in the Fundus

Cited by 6 publications

References 7 publications

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

Angioid Streaks Remain a Challenge in Diagnosis, Management, and Treatment

An update on the ocular phenotype in patients with pseudoxanthoma elasticum

Multifocal and recurrent (serous) choroidopathy (MARC) syndrome: A new variety of idiopathic central serous choroidopathy

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