Palladium catalysed selective double insertion of isonitriles into aryl bromides with trapping by sodium alkoxides provides an efficient 4-component synthesis of unusual alpha-iminoimidates.
Zinnfreie Dreikomponentenkupplung: Die palladiumkatalysierte Kupplung von Aryl‐ oder Heteroarylbromiden, primären oder sekundären Aminen und tert‐Butylisocyanid liefert pharmazeutisch interessante Arylamidine in hohen Ausbeuten [Gl. (1)]. dppf=1,1′‐Bis(diphenylphosphanyl)ferrocen; R1/R2=Bu/H, Ph/H, −(CH2)4−.
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