Purpose Urinary antiseptics including methenamine and methylene blue are used in the symptomatic treatment of urinary tract infections (UTIs). Patients and Methods This was a prospective, double-blind, randomized, double-dummy safety and efficacy study of 2 urinary antiseptic combinations in the symptomatic treatment of recurrent cystitis: methenamine 120mg + methylene blue 20mg (Group A) versus acriflavine 15mg + methenamine 250mg + methylene blue 20mg + Atropa belladonna L. 15mg (Group B). All subjects underwent pretreatment urine culture and antibiotic sensitivity tests prior to 3-day oral treatment with study drug, followed by 3 days of antibiotic therapy (based on urine culture) + study drug treatment. Efficacy was evaluated using the Urinary Tract Infection Symptoms Assessment Questionnaire (UTISA). The primary endpoint was the percentage of patients presenting improvement in cystitis manifestations on the UTISA domain “Urination Regularity” at Visit 2. The primary safety variable was the incidence of treatment-related adverse events. Results A total of 144 subjects were randomized per group and 272 completed the study. Primary endpoint analysis demonstrates homogeneity between treatment groups, with 69.4% and 72.2% subjects, respectively, showing improvement in the score of the urinary regularity UTISA domain after 3 days of treatment ( p = 0.87). At Visit 2, incidence of treatment-related adverse events was higher in Group B (Group A: n= 11, Group B: n= 31, p = 0.0057). Conclusion Both treatments were effective in reducing UTI symptoms assessed by UTISA questionnaire after 3 days of treatment. The two regimens were comparable in incidence of adverse events, but the combination of methenamine + methylene blue resulted in fewer treatment-related adverse effects.
Justifica-se esta publicação por versar sobre um caso de tumor do acústico, operado com conservação do ramo coclear e apreciável melhoria da audição, e sacrifício do ramo vestibular no qual sediava, porém com readaptação do equilíbrio pelo cerebelo cuidadosamente conservado. Não são desconhecidos casos idênticos e até admite-se uma predominância dos neurinomas de início no ramo vestibular. A constituição do ramo coclear por fibras sensorials é menos propícia à formação desses tumores. Acontece, porém, que, em geral, o diagnóstico de tumor do acústico só é firmado muito tardiamente, quando todo o nervo está comprometido pela neoformação ou pela compressão decorrente. Daí um quadro sintomatológico patognomônico que inclui os indícios do sofrimento coclear, e a surdez apontada como seqüela normal da operação dos tumores do acústico.Por outro lado, a evolução da tática neurocirúrgica e a melhoria da técnica têm possibilitado intervenções completas nos pontos mais profundos do sistema nervoso com menor traumatismo do tecido nobre e, no caso particular, a retirada dos tumores do ângulo pontocerebelar sem o sacrifício parcial do cerebelo e sem grande manuseio desse órgão, possibilitam os resultados brilhantes da suplência vestibular pelo cerebelo.Quanto aos riscos operatórios, a simplificação da intervenção e a brevidade do período pós-operatório fizeram modificar completamente o conceito clássico de gravidade dos tumores do acústico, que passaram a figurar nas estatísticas neurocirúrgicas com índices favoráveis.Para tanto, faz-se mister precocidade no diagnóstico neurológico e aprimoramento da técnica operatória. Deveremos doravante prescindir do zumbido e da surdez, que só aparecem com o sofrimento do coclear, como elementos alertadores para a suspeita diagnostica, e encarecer a análise do vestibular, principalmente pelas provas de excitação dos canais semicirculares. Também as modificações da sensibilidade craniana faltam com freqüência em tais casos. As alterações do liqüido cefalorraquidiano e as modificações radiográficas apenas se apresentam quando grandes os tumores.Trabalho apresentado ao V Congresso Inter-americano de Cirurgia reunido em La Paz (Bolívia) em 21-10-1948.
The most common cause of spinal cord injury are high impact trauma, which often result in some motor impairment, sensory or autonomic a greater or lesser extent in the distal areas the level of trauma. In terms of survival and complications due to sequelae, veterinary patients have a poor prognosis unfavorable. Therefore justified the study of experimental models of spinal cord injury production that could provide more support to research potential treatments for spinal cord injuries in medicine and veterinary medicine. Preclinical studies of acute spinal cord injury require an experimental animal model easily reproducible. The most common experimental animal model is the rat, and several techniques for producing a spinal cord injury. The objective of this study was to describe and evaluate the effectiveness of acute spinal cord injury production technique through inflation of Fogarty® catheter using rabbits as an experimental model because it is a species that has fewer conclusive publications and contemplating. The main requirements of a model as low cost, handling convenience, reproducibility and uniformity. The technique was adequate for performing preclinical studies in neuro-traumatology area, effectively leading to degeneration and necrosis of the nervous tissue fostering the emergence of acute paraplegia.
Nachstehender Beitrag ist von Interesse, da es sich um einen Acusticustumor handelt, bei dem man bei der Operation den Ram. cochlear. erhalten konnte. Nach der Operation trat eine merkliche Besserung des Hörvermögens ein. Der Ram. vestib., in dessen Bereich sich die Geschwulst befand, mußte preisgegeben werden. Da man aber sorgfältig eine Schädigung des Kleinhirns vermieden hatte, so kam es zu einer Wiederanpassung des Gleichgewichtes. Derartige Fälle sind nicht unbekannt
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