1 Diacetolol is the N‐acetylated metabolite of acebutolol and possesses beta‐adrenergic receptor blocking properties. 2 Its antihypertensive action was assessed in accordance with a double‐blind randomised cross‐ over scheme in 17 patients with moderate essential hypertension previously well controlled with acebutolol. 3 Significant reductions in lying mean arterial blood pressure were observed with daily doses of 200 mg (‐ 9%), 400 mg (‐ 10%) and 800 mg (‐ 14%), and were associated with significant decreases in heart rate and plasma renin activity. 4 The diacetolol mean plasma level measured 8 to 10 h after drug ingestion was proportional to the dose (207 +/‐ 27, 394 +/‐ 63 and 823 +/‐ 135 ng/ml for respectively 200, 400 and 800 mg/day).
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