Antihypertensive effect of diacetolol in essential hypertension.

Thibonnier, Marc; Flabeau, C; Thouvenin, Marie‐Dominique; Roux, A; Flouvat, B; Pasquier, Philippe; Ménard, J

doi:10.1111/j.1365-2125.1982.tb01417.x

Cited by 2 publications

(2 citation statements)

References 9 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bronchial ,B-adrenoceptor blocking effects of diacetolol, an active metabolite of acebutolol (Thibonnier et al, 1982), have never been studied in humans but they appeared, in our results, to be very similar to those of the parent-compound.…”

Section: Discussionsupporting

confidence: 49%

Comparative beta‐adrenoceptor blocking effects of propranolol, bisoprolol, atenolol, acebutolol and diacetolol on the human isolated bronchus.

Naline¹,

Sarriá²,

Ertzbischoff³

et al. 1990

Brit J Clinical Pharma

View full text Add to dashboard Cite

Cedex 06 and 2Laboratoires Lederle, 74, rue d'Arcueil, SILIC 275, 94578 Rungis Cedex, France Five P-adrenoceptor blockers, propranolol, acebutolol, diacebutolol, atenolol and bisoprolol, were tested for their antagonistic effect against isoprenaline on human isolated bronchi. The results showed (1) that only propranolol exerted a competitive antagonistic effect against isoprenaline (pA2 = 9.40 ± 0.22, n = 7) whereas the other drugs did not, and (2) that, in the presence of P-adrenoceptor blockers in the plasma concentrations reported after a single usual therapeutic dose, the doses of isoprenaline giving the same bronchodilator effect must be multiplied by 32.6, 5.51, 4.63, 2.82 and 1.95 respectively with propranolol, diacetolol, acebutolol, atenolol, and bisoprolol. It was concluded that (1) atenolol and bisoprolol were the least potent drugs at bronchial level in therapeutic plasma concentrations and (2) that tests performed on the human isolated bronchus might be a useful screening procedure for new drugs with potential activity on the airways.

show abstract

Section: Discussionsupporting

confidence: 49%

Comparative beta‐adrenoceptor blocking effects of propranolol, bisoprolol, atenolol, acebutolol and diacetolol on the human isolated bronchus.

Naline¹,

Sarriá²,

Ertzbischoff³

et al. 1990

Brit J Clinical Pharma

View full text Add to dashboard Cite

show abstract

“…After the oral dose, peak plasma levels were obtained at approximately 2 h, with an initial elimination half-life of about 3 hours and a terminal elimination half-life of about 15 hours (Gulaid, 1981). An active metabolite, diacetolol (Thibonnier, 1982), has been identified with higher blood levels and slower clearance than the parent compound.…”

Section: Discussionmentioning

confidence: 99%

The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives

Mehta

Goldberg

Walsh

1985

Clinical Cardiology

View full text Add to dashboard Cite

Summary: Intra-arterial blood pressure recordings were studied in 10 ambulant subjects with essential hypertension to evaluate the effect of a single daily dose of acebutolol. Blood pressures and heart rates, measured on a beat-to-beat basis were averaged over every hour, for the daytime, night-time, and for the total 24 hours. Acebutolol significantly lowered the average daytime systolic pressure (160 to 142 mmHg, p = <0.01), diastolic pressure (78 to 66 d g , p = <0.01), and the heart rate (92 to 77 beatshin, p = <0.001). Significantly lower pressures were demonstrated up to 11 hours after the last dose of acebutolol. The effect on heart rate lasted up to 13 hours. The observed lowering of pressures and heart rate during the remaining 11 hours did not reach statistical significance.

show abstract

Antihypertensive effect of diacetolol in essential hypertension.

Cited by 2 publications

References 9 publications

Comparative beta‐adrenoceptor blocking effects of propranolol, bisoprolol, atenolol, acebutolol and diacetolol on the human isolated bronchus.

Comparative beta‐adrenoceptor blocking effects of propranolol, bisoprolol, atenolol, acebutolol and diacetolol on the human isolated bronchus.

The lowering of daytime blood pressures with a single daily dose of acebutolol in ambulant hypertensives

Contact Info

Product

Resources

About