Transition-Metal-Assisted Asymmetric Synthesis of Amino Acid Analogues. A New Synthesis of Optically Pure D-and L-Pyridylalanines.-Palladium-catalyzed reaction of the bromopyridines (I) with the acetylaminoacrylate (II) yields the coupling product (III) which is hydrogenated asymmetrically in the presence of a chiral rhodium catalyst and subsequently deprotected to produce the pyridylalanines ( L)-(V). The corresponding (D)pyridylalanines are prepared using the enantiomeric rhodium catalyst.-(BOZELL, J. J.; VOGT, C. E.; GOZUM, J.; J. Org. Chem. 56 (1991Chem. 56 ( ) 7, 2584Chem. 56 ( -2587 Corp. Res. Dev., Monsanto Co., St. Louis, MO 63167, USA; EN)
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