Oral administration of carbamazepine (CBZ) (15, 10, or 5 mg/kg) to mice significantly decreased both humoral and cellular immune responses evaluated by enumeration of direct and indirect plaque-forming spleen cells (PFC) and delayed-type hypersensitivity reaction (DTH) against sheep red blood cells (SRBC) as compared with those observed in normal control animals. Moreover, spleen T cells obtained from CBZ-treated donor mice were capable of decreasing both PFC and DTH responses of normal spleen cells transferred into lethally irradiated recipient animals. The immunodepressor effect of CBZ was observed even though administration of CBZ induced augmentation of spleen cellularity.
After the intraperitoneal injection of aclacinomycin into mice, a variety of immune responses were increased. The total plaque-forming spleen cell response to SRBC was higher in treated animals than in controls, in spite of an apparent cytotoxic effects on B cells. The aclacinomycin-sensitive cell is apparently a long-lived cell, surviving adult thymectomy. Delayed-type hypersensitivity reactions were also augmented in treated animals, particularly those bearing tumors. In adjuvant-treated mice, the injection of aclacinomycin augments the immune response still further. Such observations should be taken into account in the establishment of clinical protocols associating immunotherapy and chemotherapy.
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