Effects of phenytoin administration on murine immune function

Andrade-Mena, C.E.; Sardo‐Olmedo, J. A. J.; Ramírez-Lizardo, Ernesto Javier

doi:10.1016/0165-5728(94)90208-9

Cited by 14 publications

(8 citation statements)

References 21 publications

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“…Thus, gonadal or sexsteroid effects on susceptibility to cysticercosis seems to be mediated via the immune system rather than a direct action upon the parasites. 7,28,40 Interestingly, the frequently administered antiepileptic drugs (in patients with NCC), such as carbamazepine and phenytoin, can also alter immune function 2,3 and, therefore, could affect susceptibility to parasitic infestation.…”

Section: Resultsmentioning

confidence: 99%

Spinal cord cysticercosis: neurosurgical aspects

Colli¹,

Valênça²,

Carlotti³

et al. 2002

FOC

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Object The authors report their experience in the treatment of 12 symptomatic patients with intradural spinal neurocysticercosis. Methods The mean age of the 12 patients was 33 years. There were eight female and four male patients. Cysticercosis was present in association with hydrocephalus in nine cases. In nine of 12 patients the spinal lesion was confined to the thoracic or lumbar spinal cord, and in three the cysticerci occupied the cervical region. In all patients with hydrocephalus nerve root symptoms developed seven to 48 months later (mean 27.6 ± 15.5 months). In one patient hydrocephalus was absent, but he presented with cysticercal meningitis 24 months before spinal cord compression developed. Presenting symptoms suggesting spinal cysticercosis included muscular weakness (67%), pain (67%), and sphincter disturbance (25%). Neurological examination demonstrated a motor deficit in nine patients, sensory deficit in four, and radicular pain in three. The prognosis was worse in patients with moderate-to-severe arachnoiditis and spinal cord compression compared with those with isolated nerve roots involvement in whom outcome was favorable. Ten patients underwent laminectomy, after which neurological status improved in 44%, remained unchanged in 33%, or worsened in 22.2%. Conclusions The authors discuss their findings in these cases. Additionally they briefly review the literature, patho-physiology, and therapeutic and/or surgical strategies involved in this disease.

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Section: Resultsmentioning

confidence: 99%

Spinal cord cysticercosis: neurosurgical aspects

Colli¹,

Valênça²,

Carlotti³

et al. 2002

FOC

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“…The mechanisms responsible for depression of humoral and cellular immunity by phenytoin are unknown, but studies in mice indicate a CD8 + cellmediated inhibitory effect. 35 Accepted for publication March 1, 2000 …”

Section: Immunological Consequences Of Long-term Treatment With Antiementioning

confidence: 98%

Epilepsy and the Immune System

Aarli¹

2000

Arch Neurol

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“…Moreover, immune functions affected by chronic administration of phenytoin also have been elucidated in humans and rodents both in vivo and in vitro [5–9]. Some animal studies have suggested that the chronic administration of phenytoin reduced the immune response against infectious and malignant diseases [10,11], but the mechanism of phenytoin‐induced immune suppression is not clear. Recent studies have clarified the existence of Th1/Th2 CD4 + T cell subsets which were functionally heterogeneous populations with specific profiles of cytokine production.…”

Section: Introductionmentioning

confidence: 99%

Phenytoin promotes Th2 type immune response in mice

Okada

Sugiura²,

Kuroda³

et al. 2001

Clinical and Experimental Immunology

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The effects of chronic administration of phenytoin, a common anticonvulsive drug, on immune responses were studied in mice. Anti‐keyhole limpet haemocyanin (KLH) IgE antibody response after KLH‐immunization was enhanced in phenytoin‐treated mice. Proliferative responses of spleen cells induced with KLH, concanavalin A (ConA), lipopolysaccharide and anti‐CD3 antibody were reduced in phenytoin‐treated mice. Accessory function of spleen adherent cells on ConA‐induced T cell proliferative response was reduced in phenytoin‐treated mice. KLH‐induced IL‐4 production of spleen cells was enhanced, while IFN‐γ production was reduced in phenytoin‐treated mice. In addition, production of IL‐1α, but not IL‐6 and IL‐12 by spleen adherent cells from phenytoin‐treated mice was reduced. Natural killer cell activity was reduced in phenytoin‐treated mice. These results suggest that phenytoin treatment preferentially induces a Th2 type response. We also observed that plasma ACTH and corticosterone levels were increased in phenytoin‐treated mice, and speculated that phenytoin might act directly and indirectly, through HPA axis activation, on the immune system to modulate Th1/Th2 balance.

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Effects of phenytoin administration on murine immune function

Cited by 14 publications

References 21 publications

Spinal cord cysticercosis: neurosurgical aspects

Spinal cord cysticercosis: neurosurgical aspects

Epilepsy and the Immune System

Phenytoin promotes Th2 type immune response in mice

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