Laryngeal neoplasm contributes to 30-40% of carcinomas of the head and neck.
Mast cells are normal connective tissue residents, well represented in the
respiratory tract. Experimental evidence suggests that the growth of a tumor
beyond a certain size requires angiogenesis, which may also permit
metastasis. The aim of this study was to evaluate the correlation between
mast cell density, microvascular density, histopathological type and
histological grade. Our study included 38 laryngeal carcinomas as follows:
adenoid cystic carcinoma (2 cases), malignant papilloma (2 cases) and
squamous cell carcinoma (34 cases). The combined technique of CD 34-alcian
blue safranin (ABS) was used to identify microvessel and mast cell density,
which was quantified by the hot spot method. A significant correlation was
found between both mast cell and microvascular density, and G1/G2
histological grade (p=0.002 and p=0.004, respectively). Squamous cell
carcinoma was significantly correlated with mast cell density (p=0.003), but
not with microvascular density (p=0.454).
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