Mixed gonadal dysgenesis and ovotesticular disorders of sex development, are rare conditions that occur sporadically, with unknown prevalence. Clinical manifestation of this diseases is sexual ambiguity. The authors present a pediatric case with sexual ambiguity and karyotype 45, X/46, XY, the child of a HIV-positive mother receiving multiple antiretroviral treatments for a period of 16 years.
AbstractsWe report on a 35 year-old woman with arterial hypertension who was referred to our obstetrical department because of oligohydramnios. She reported to receive treatment with Olmesartanmedoxomil (5mg/day). The condition resolved after changing anti-hypertensive treatment to metoprolol at 26 6/7 weeks of pregnancy. The patient was born at term by C-section and showed the following signs of fetopathy: hyperechogenic multicystic kidneys and hypocalvaria. Renal function was normal, nevertheless arterial hypertension was present but treatment was not required. Discharge from hospital was possible at the age of 9 days. Regularly follow-up visits are necessary to monitor renal function and to evaluate long term effects.Incidence of sartan-related fetopathy is unknown, therefore consistent reporting is mandatory. We present a case with mild presentation of symptoms, probably related to low therapeutic dosage and early change of antihypertensive treatment. AII: distribution of children according to sex M/F=27/14, social environment U/R=18/23, age group (years): 0-1/1-3/3-5/ 5-10/10-14/14-16=11/10/9/5/4/2; etiologic spectrum: drugs in 9 children, nitrates in 7, carbon monoxide 7, mushrooms 6, corrosive substances 5, insecticides/anti-parasitary 3, ethylic alcohol 2, medicinal alcohol 1, and acetone 1. EPIDEMIOLOGICAL STUDY ON ACUTE INTOXICATIONSIn AVI, the sex ratio was M/F=21/33, social environment U/ R=27/27, age group (years): 5-10/10-14/14-16=12/17/25. Causes of AVI: drugs in 32, ethylic alcohol 12, ethno-botanical 4, corrosive substances 3, unknown causes 2, caffeine 1 case. There were registered 2 deaths because of nitrates intoxication, in rural infants, aged 1 and 2 months.Average period of hospitalization (days): in AII 4.79±3.12 (1-16), in AVI 3.25±1.3 (1-10). Conclusions AI represented 4.1% of the total admitted cases. Drugs represented the most frequent cause both in AII and AVI. AII were more frequent in males and rural areas; AVI prevailed in females. Deaths because of AI represented 2.1% of the total number of AI cases. doi:10.1136/archdischild-2012-302724.1650 Side efects of antibiotics must always be considered, especialy in neonatal period. Our aim was to analise the antibiotic use in our neonatal ward(2nd level perinatal care).We analised number of babies who received therapy, indications and time of starting antibiotics, duration and antibiotis used, laboratory analysis (CBC, CRP, swabs and cultures of babies and mothers))and discharge diagnosis in one-year period. ACUTE INTOXICATIONS WITH DRUG SUBSTANCES IN CHILDREN -A CLINICAL EPIDEMIOLOGICAL STUDY RATIONAL USE OF ANTIBIOTICS IN NEWBORN2299 babies were born in 2011, and 125(5.4%) recived antibiotics.49% had risk factors for infection. In 62% therapy started in 1st or 2nd day of life, and average duration was 5-7 days, in 83%. Ampicillin+Gentamycin was given in 82%; Ampicillin for GBS colonisation and cefalosporines for UTI. There were no multiresistant strains. Diagnosis Respiratory: 43 (34.4%), Asphyxia: 17 (13.6%), Urinary tract infections...
AbstractsWe report on a 35 year-old woman with arterial hypertension who was referred to our obstetrical department because of oligohydramnios. She reported to receive treatment with Olmesartanmedoxomil (5mg/day). The condition resolved after changing anti-hypertensive treatment to metoprolol at 26 6/7 weeks of pregnancy. The patient was born at term by C-section and showed the following signs of fetopathy: hyperechogenic multicystic kidneys and hypocalvaria. Renal function was normal, nevertheless arterial hypertension was present but treatment was not required. Discharge from hospital was possible at the age of 9 days. Regularly follow-up visits are necessary to monitor renal function and to evaluate long term effects.Incidence of sartan-related fetopathy is unknown, therefore consistent reporting is mandatory. We present a case with mild presentation of symptoms, probably related to low therapeutic dosage and early change of antihypertensive treatment. AII: distribution of children according to sex M/F=27/14, social environment U/R=18/23, age group (years): 0-1/1-3/3-5/ 5-10/10-14/14-16=11/10/9/5/4/2; etiologic spectrum: drugs in 9 children, nitrates in 7, carbon monoxide 7, mushrooms 6, corrosive substances 5, insecticides/anti-parasitary 3, ethylic alcohol 2, medicinal alcohol 1, and acetone 1. EPIDEMIOLOGICAL STUDY ON ACUTE INTOXICATIONSIn AVI, the sex ratio was M/F=21/33, social environment U/ R=27/27, age group (years): 5-10/10-14/14-16=12/17/25. Causes of AVI: drugs in 32, ethylic alcohol 12, ethno-botanical 4, corrosive substances 3, unknown causes 2, caffeine 1 case. There were registered 2 deaths because of nitrates intoxication, in rural infants, aged 1 and 2 months.Average period of hospitalization (days): in AII 4.79±3.12 (1-16), in AVI 3.25±1.3 (1-10). Conclusions AI represented 4.1% of the total admitted cases. Drugs represented the most frequent cause both in AII and AVI. AII were more frequent in males and rural areas; AVI prevailed in females. Deaths because of AI represented 2.1% of the total number of AI cases. doi:10.1136/archdischild-2012-302724.1650 Side efects of antibiotics must always be considered, especialy in neonatal period. Our aim was to analise the antibiotic use in our neonatal ward(2nd level perinatal care).We analised number of babies who received therapy, indications and time of starting antibiotics, duration and antibiotis used, laboratory analysis (CBC, CRP, swabs and cultures of babies and mothers))and discharge diagnosis in one-year period. ACUTE INTOXICATIONS WITH DRUG SUBSTANCES IN CHILDREN -A CLINICAL EPIDEMIOLOGICAL STUDY RATIONAL USE OF ANTIBIOTICS IN NEWBORN2299 babies were born in 2011, and 125(5.4%) recived antibiotics.49% had risk factors for infection. In 62% therapy started in 1st or 2nd day of life, and average duration was 5-7 days, in 83%. Ampicillin+Gentamycin was given in 82%; Ampicillin for GBS colonisation and cefalosporines for UTI. There were no multiresistant strains. Diagnosis Respiratory: 43 (34.4%), Asphyxia: 17 (13.6%), Urinary tract infections...
Obiective. Hemoragiile peri-intraventriculare (HPIV) pot determina la sugarii născuţi prematur diferite grade de retard neuropsihomotor. Un studiu prospectiv efectuat în IOMC pe o perioadă de 4 ani (2009-2012), pe un lot de 160 prematuri, a urmărit prevalenţa gradelor de HPIV diagnosticate prin ecografie transfontanelară (ETF), identificarea factorilor de risc asociaţi şi a severităţii afectării neurologice la aceşti pacienţi prin urmărirea lor pe o perioadă de 12 luni. Material şi metodă. Pe perioada studiului, prematurii internaţi în IOMC au fost examinaţi sistematic prin ETF, printr-un protocol standardizat; aprecierea gradelor HPIV s-a efectuat conform clasificării Papile. Evaluarea neurologică a fost efectuată sistematic până la vârsta de 1 an. Rezultate. Cel mai frecvent înregistrate au fost HPIV I şi II – 45%, respectiv 37,5% din numărul total de pacienţi. HPIV gradul IV au reprezentat 4,4%. În HPIV grad I şi II afectarea neurologică a fost uşoară, această corelaţie având semnificaţie statistică (p < 0,01) pentru ambele forme. Hemoragiile gradul III şi IV au fost asociate cu o evoluţie neurologică nefavorabilă, corelaţia între HPIV grad IV şi sechelele neurologice majore având semnificaţie statistică (p < 0,01). Concluzii. ETF efectuată de rutină tuturor prematurilor permite diagnosticul precoce şi stadializarea HPIV, aprecierea evoluţiei neurologice cu instituirea precoce a tratamentului şi asigurarea consilierii adecvate.
Objectives. In preterm babies, peri-intraventricular hemorrhages (PIVH) might cause various degrees of neuropsycho-motor impairment. A 4-year prospective study (2009-2012) performed in the IOMC, was aimed to determine the prevalence of different degrees of PIVH diagnosed by head ultrasound (HUS) among 160 admitted preterm babies, the associated risk factors, along with the neuro-developmental effects on a 12-month follow-up period. Material and methods. In the above-mentioned period all admitted preterms were examined by transfontanelar ultrasound according to a standardized protocol based on Papile’s PIVH classification. For those preterms included in the study a 12-month systematic neurologic follow-up was performed. Results. PIVH grade I (45%) and II (37,5%) were the most prevalent types. Grade IV PIVH represented 4,4% from all PIVH cases. The good neurological outcome of grade I and II PIVH, was found to be statistically significant (p < 0.01) for both types. Severe neurological sequelae were associated with grade III and IV and a statistically significant correlation (p<0.01) was found only for grade IV hemorrhages. Conclusion. Systematic HUS screenings for all preterm babies is useful for early diagnosis and PIVH staging, for neurologic outcome prediction, providing the appropriate management strategy and a well-suited parental counseling.
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