AbstractsWe report on a 35 year-old woman with arterial hypertension who was referred to our obstetrical department because of oligohydramnios. She reported to receive treatment with Olmesartanmedoxomil (5mg/day). The condition resolved after changing anti-hypertensive treatment to metoprolol at 26 6/7 weeks of pregnancy. The patient was born at term by C-section and showed the following signs of fetopathy: hyperechogenic multicystic kidneys and hypocalvaria. Renal function was normal, nevertheless arterial hypertension was present but treatment was not required. Discharge from hospital was possible at the age of 9 days. Regularly follow-up visits are necessary to monitor renal function and to evaluate long term effects.Incidence of sartan-related fetopathy is unknown, therefore consistent reporting is mandatory. We present a case with mild presentation of symptoms, probably related to low therapeutic dosage and early change of antihypertensive treatment. AII: distribution of children according to sex M/F=27/14, social environment U/R=18/23, age group (years): 0-1/1-3/3-5/ 5-10/10-14/14-16=11/10/9/5/4/2; etiologic spectrum: drugs in 9 children, nitrates in 7, carbon monoxide 7, mushrooms 6, corrosive substances 5, insecticides/anti-parasitary 3, ethylic alcohol 2, medicinal alcohol 1, and acetone 1. EPIDEMIOLOGICAL STUDY ON ACUTE INTOXICATIONSIn AVI, the sex ratio was M/F=21/33, social environment U/ R=27/27, age group (years): 5-10/10-14/14-16=12/17/25. Causes of AVI: drugs in 32, ethylic alcohol 12, ethno-botanical 4, corrosive substances 3, unknown causes 2, caffeine 1 case. There were registered 2 deaths because of nitrates intoxication, in rural infants, aged 1 and 2 months.Average period of hospitalization (days): in AII 4.79±3.12 (1-16), in AVI 3.25±1.3 (1-10). Conclusions AI represented 4.1% of the total admitted cases. Drugs represented the most frequent cause both in AII and AVI. AII were more frequent in males and rural areas; AVI prevailed in females. Deaths because of AI represented 2.1% of the total number of AI cases. doi:10.1136/archdischild-2012-302724.1650 Side efects of antibiotics must always be considered, especialy in neonatal period. Our aim was to analise the antibiotic use in our neonatal ward(2nd level perinatal care).We analised number of babies who received therapy, indications and time of starting antibiotics, duration and antibiotis used, laboratory analysis (CBC, CRP, swabs and cultures of babies and mothers))and discharge diagnosis in one-year period. ACUTE INTOXICATIONS WITH DRUG SUBSTANCES IN CHILDREN -A CLINICAL EPIDEMIOLOGICAL STUDY RATIONAL USE OF ANTIBIOTICS IN NEWBORN2299 babies were born in 2011, and 125(5.4%) recived antibiotics.49% had risk factors for infection. In 62% therapy started in 1st or 2nd day of life, and average duration was 5-7 days, in 83%. Ampicillin+Gentamycin was given in 82%; Ampicillin for GBS colonisation and cefalosporines for UTI. There were no multiresistant strains. Diagnosis Respiratory: 43 (34.4%), Asphyxia: 17 (13.6%), Urinary tract infections...
AbstractsWe report on a 35 year-old woman with arterial hypertension who was referred to our obstetrical department because of oligohydramnios. She reported to receive treatment with Olmesartanmedoxomil (5mg/day). The condition resolved after changing anti-hypertensive treatment to metoprolol at 26 6/7 weeks of pregnancy. The patient was born at term by C-section and showed the following signs of fetopathy: hyperechogenic multicystic kidneys and hypocalvaria. Renal function was normal, nevertheless arterial hypertension was present but treatment was not required. Discharge from hospital was possible at the age of 9 days. Regularly follow-up visits are necessary to monitor renal function and to evaluate long term effects.Incidence of sartan-related fetopathy is unknown, therefore consistent reporting is mandatory. We present a case with mild presentation of symptoms, probably related to low therapeutic dosage and early change of antihypertensive treatment. AII: distribution of children according to sex M/F=27/14, social environment U/R=18/23, age group (years): 0-1/1-3/3-5/ 5-10/10-14/14-16=11/10/9/5/4/2; etiologic spectrum: drugs in 9 children, nitrates in 7, carbon monoxide 7, mushrooms 6, corrosive substances 5, insecticides/anti-parasitary 3, ethylic alcohol 2, medicinal alcohol 1, and acetone 1. EPIDEMIOLOGICAL STUDY ON ACUTE INTOXICATIONSIn AVI, the sex ratio was M/F=21/33, social environment U/ R=27/27, age group (years): 5-10/10-14/14-16=12/17/25. Causes of AVI: drugs in 32, ethylic alcohol 12, ethno-botanical 4, corrosive substances 3, unknown causes 2, caffeine 1 case. There were registered 2 deaths because of nitrates intoxication, in rural infants, aged 1 and 2 months.Average period of hospitalization (days): in AII 4.79±3.12 (1-16), in AVI 3.25±1.3 (1-10). Conclusions AI represented 4.1% of the total admitted cases. Drugs represented the most frequent cause both in AII and AVI. AII were more frequent in males and rural areas; AVI prevailed in females. Deaths because of AI represented 2.1% of the total number of AI cases. doi:10.1136/archdischild-2012-302724.1650 Side efects of antibiotics must always be considered, especialy in neonatal period. Our aim was to analise the antibiotic use in our neonatal ward(2nd level perinatal care).We analised number of babies who received therapy, indications and time of starting antibiotics, duration and antibiotis used, laboratory analysis (CBC, CRP, swabs and cultures of babies and mothers))and discharge diagnosis in one-year period. ACUTE INTOXICATIONS WITH DRUG SUBSTANCES IN CHILDREN -A CLINICAL EPIDEMIOLOGICAL STUDY RATIONAL USE OF ANTIBIOTICS IN NEWBORN2299 babies were born in 2011, and 125(5.4%) recived antibiotics.49% had risk factors for infection. In 62% therapy started in 1st or 2nd day of life, and average duration was 5-7 days, in 83%. Ampicillin+Gentamycin was given in 82%; Ampicillin for GBS colonisation and cefalosporines for UTI. There were no multiresistant strains. Diagnosis Respiratory: 43 (34.4%), Asphyxia: 17 (13.6%), Urinary tract infections...
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