Sera taken from pregnant patients and their newborns at delivery were examined for evidence of primary or reactivated Epstein-Barr virus infection. Of 102 women, 37 showed serological signs of reactivated and two signs of primary infection. A mild congenital defect was observed in association with one of the two cases of maternal primary infection. Infants of mothers with reactivated infections remained healthy during the one year follow-up after birth.
3-Hydrazinopyridazines substituted in position 6 with a primary amine, secondary amine, or an alkoxy group were synthesized and screened for antihypertensive activity. In general, the 6-dialklamino derivatives are the most active; the (2-hydroxypropyl)methylamino chain provides the best combination of high antihypertensive activity and toxicity.
SummaryThe influence of environmental pH on eytomegalovirus replication cycle was studied. A productive cycle was observed at pH values of 6.5 or higher while at pH values of 5.8, 6.0, 6.2 only virus-induced early events were expressed.
,It has been previously shown that the development of some viruses, such as vesicular stomatitis virus (VSV) (3), poliovirus (11) and herpes simplex virus (4) can be affected by environmental pH.I~OLZMA~ (t0), studying the relationship between different strains of herpes simplex virus {HSV) and the pH of the medium, has shown that the optimal extracellular pH for HSV multiplication may vary between 6.5--7.3. Furthermore Lh~cz and Bt~ADSTREET (4) demonstrated that an overlay medium at pH 6.3 completely inhibits plaque formation by herpes simplex virus but not its replication.Little is known, however, about the effect of extracellular pH on the replication cycle of human cytomegalovirus (HCMV). HCMV is characterized by a long replication cycle and, in contrast to what happens in cells infected by other cytocidal herpesviruses, host cell macromolecule synthesis is not inhibited. In fact, cells infected by HCMV show increased RNA (13) and DNA (12) synthesis and various cellular enzymes are stimulated; all this suggests that cellular functions are probably involved in HCMV replication and this is supported by the fact that in actinomyein pretreated cells a complete rep]ieation cycle of HCMV is inhibited (5). All these data prompted us to study the influence of environmental pH on the replication cycle of HCMV.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.