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gen bonds with an a-functionalized carboxylic acid as the guest 6 , = 5.21 6,, = 0.69 / ( 9 -5 (4-1 P.

The pyruvic acid dimethyl hydrazone can be easily prepared in ether. This compound, after deprotonation with alkyllithium, forms a strong nucleophile which on treatment with electrophiles and acidic work up yield α-ketoacids, α-hydroxybutenolides or α,γ-diketoacids.

The ditopic neutral receptors 1 and 2 were synthesized for the recognition and sensing of bis-carboxylates. They are based on pyrrole and amide groups as hydrogen-bond donors to bind the oxoanions of the guests. Among the obtained results, the selectivity for glutarate over succinate is particularly interesting. Compound 1 behaves as a PET fluorescence sensor for glutarate.