Background This paper examines the perceived quality of working life of workers with intellectual disabilities. Specifically, this paper looks at participants’ perceptions in relation to perceived job demands and resources and their impact on experienced job satisfaction.
Methods In this cross‐sectional survey, 507 workers with intellectual disabilities, employed in either sheltered workshops or supported employment, completed questionnaires on the quality of working life through semi‐structured interviews.
Results Regression analyses showed that perceived low job demands and elevated social support from coworkers and supervisors predicted higher quality of working life.
Conclusions Common organizational psychology measures can be successfully used with this population to assess quality of working life. This study confirms the multidimensional nature of quality of working life, and the impact of job demands and available resources on perceived satisfaction with job for workers with intellectual disabilities.
A procedure for the enantioselective preparation of tetrasubstituted medium sized cyclic ethers is presented. An oxocane is prepared by a sequence which involves a double diastereoselective hetero Diels-Alder reaction between a chiral aldehyde and a diene bearing an allylic chiral centre. The cycloadduct is transformed into a linear ether which is then converted to the cyclic ether by a highly regioselective intramolecular alkylation of a lithiosulfone with an epoxide. The sense of induction of the chiral centre on the diene is discussed.Medium sized cyclic ethers, substituted at the positions adjacent to the oxygen atom (a, a',b, b') have attracted considerable interest because they constitute the basic skeleton of many metabolites isolated mainly from marine sources, 1 and also because they are the basic units of the important fused polyether marine toxins. 2 In these latter compounds, the most usual relative stereochemistry of the substituents in each of the fused cyclic ethers is trans, syn, trans (Figure 1).
Figure 1We have recently reported on a methodology for the enantioselective preparation of medium sized, bi-and trisubstituted cyclic ethers using an intramolecular alkylation of a lithiosulfone with an epoxide. 3 The control over the relative stereochemistry of the substituents is attained by the use of a hetero Diels-Alder reaction between a monoactivated diene and a chiral aldehyde.In this communication we present the extension of this methodology to the preparation of cyclic ethers tetrasubstituted at the a, a', b, and b' positions. Scheme 1 shows a retrosynthetic scheme for the preparation of a tetrasubstituted oxocane, based on the methodology previously used for trisubstituted systems. For this scheme to be successful, the intramolecular cyclization reaction has to be highly regioselective, a result that can be expected based on our previous experience with similar compounds. 3b
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