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Synthesis of Novel Monocyclic Squalestatin Analogues as PotentialInhibitors of Squalene Synthase. -The synthesis of the two 1,3-dioxane tricarboxylic acid analogues (VI) and (VII) of natural squalestatin (VIII) is described as shown for (VI) . Both compounds show moderate activities against squalene synthase ( rat liver and Candida albicans).-(SHAW, R. E.; BURGESS, C.; COUSINS, R. P. C.; GIBLIN, G. M. P.; LIVERMORE, D. G. H.; SHINGLER, A. H.; SMITH, C.; YOUDS, P. M.; Bioorg. Med.

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C. Burgess

Selective Plasma Hydrolysis of Glucocorticoid γ-Lactones and Cyclic Carbonates by the Enzyme Paraoxonase: An Ideal Plasma Inactivation Mechanism

Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum

Synthesis of novel monocyclic squalestatin analogues as potential inhibitors of squalene synthase

ChemInform Abstract: Synthesis of Novel Monocyclic Squalestatin Analogues as Potential Inhibitors of Squalene Synthase.

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