A novel Cu-catalysed asymmetric conjugate addition reaction with bis[(pinacolato)boryl]methane using α,β-unsaturated enones as substrates has been developed on the basis of strategic preservation of the supporting ligand.
A novel strategy for the stereospecific Pd-catalyzed acylative cross-coupling of enantiomerically enriched alkylboron compounds has been developed. The protocol features an extremely high level of enantiospecificity to allow facile access to synthetically challenging and valuable chiral ketones and carboxylic acid derivatives. The use of a sterically encumbered and electronrich phosphine ligand proved to be crucial for the success of the reaction. Furthermore, on the basis of experimental and computational studies, a unique mechanism for the transmetalation, assisted by the noncovalent interactions of the C(sp 3 )-based organoboron reagent, has been identified.
A novel strategy for the stereospecific Pd-catalyzed acylative cross-coupling of enantiomerically enriched alkylboron compounds has been developed. The protocol features an extremely high level of enantiospecificity to allow facile access to synthetically challenging and valuable chiral ketones and carboxylic acid derivatives. The use of a sterically encumbered and electron-rich phosphine ligand proved to be crucial for the success of the reaction. Furthermore, based on experimental and computational studies, a unique mechanism for the transmetalation of the C(sp3)-based organoboron reagent has been identified. Furthermore, based on experimental and computational studies, a unique mechanism for the transmetalation of the C(sp3)-based organoboron reagent has been identified.
A novel strategy for the stereospecific Pd-catalyzed acylative cross-coupling of enantiomerically enriched alkylboron compounds has been developed. The protocol features an extremely high level of enantiospecificity to allow facile access to synthetically challenging and valuable chiral ketones and carboxylic acid derivatives. The use of a sterically encumbered and electron-rich phosphine ligand proved to be crucial for the success of the reaction. Furthermore, based on experimental and computational studies, a unique mechanism for the transmetalation of the C(sp3)-based organoboron reagent has been identified.
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