No abstract

Nature as inspired human beings since time immemorial and every member of human race, irrespective of origin and religion, keeps nature at an esteemed place. It is a common belief that everything that occurs in nature has beneficial effects as compared to products of anthropogenic origin. The medical profession is as old as the human history and so is the history of medicines. In current era, with advancement in medical science, the intensity of diseases has also increased. New medicines are being developed for the treatment of complicated diseases but these medicines are themselves associated with a number of side effects that range from minor to sever intensity. The medicines from nature on the other hand appear to be more effective than the synthetic counterpart. This short commentary deals with comparison of synthetic drugs and the drugs from nature with special emphasis on extent of side effects associated with both categories.

The asymmetric unit of the title compound, C13H10N2O4, contains two crystallographically independent mol­ecules. The aromatic rings are oriented at dihedral angles of 24.39 (3) and 7.47 (3)° in the two mol­ecules and intra­molecular N—H⋯O and O—H⋯O hydrogen bonds result in the formation of two planar six-membered rings. In the crystal structure, inter­molecular O—H⋯O and C—H⋯O hydrogen bonds link the mol­ecules into chains, forming R 2 2(10) ring motifs. Weak π–π contacts between the benzene and phenyl rings [centroid–centroid distance = 3.955 (3) Å] may further stabilize the structure.

No abstract

Novel and highly sensitive indole-based imines have been synthesized. Their synthesis has been compared employing a variety of protocols. Ultimately, a convenient, economical and high yielding set of conditions employing green chemistry have been designed for their synthesis.

Novel chiral 4,1-benzoxazepine-2,5-diones have been unusually synthesized in a single step by exploiting the chiral pool methodology. Substituted anthranilic acids afford N-acylanthranilic acids and (3R)-3-alkyl-4,1-benzoxazepines-2,5-dione upon coupling with α-chloroacids or α-bromoacids, respectively.

Background: Diabetes mellitus is an extremely common endocrine metabolic disorder that results in chronic hyperglycemia. It has effects on various tissues of the body. Due to this increased blood glucose levels considerable cellular changes occur in oral cavity as well. This field has attracted little research. The aim of the study was to analyze the changes in morphology and cytomorphometric measurements in the buccal mucosal cells of type 2 diabetic patients.

Novel 3-alkyl-4,1-benzoxazepine-2,5-diones were synthesized in good ee exploiting the chiral pool methodology, an economical way of asymmetric synthesis. Various anthranilic acids are coupled with different α-haloacids to afford N-acylated anthranilic acid intermediates which undergo cyclization to (3R)-3-alkyl-4,1-benzoxazepines-2,5-diones.