COVID-19 is a global pandemic caused by severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Being associated with high mortality rates, this pandemic has forced several countries worldwide to impose complete lockdowns to limit the spread of infection. Despite the development of various vaccines, there is still an urgent need to design novel treatments backed with safety data for fighting SARS-CoV-2 and its various mutants. Currently, scientists are putting their strenuous efforts into finding the best treatment option for COVID-19. In this regard, metal complexes being active antiviral agents and immunity enhancers have great potential against SARS-CoV-2. Herein, metal complexes' therapeutic role and significance against treating SARS-CoV-2 or any of its target proteins are discussed.
Antimicrobial resistance of microbes against treatment that once could cure, has inspired an urgent need for new drugs development. Accordingly, three binuclear Zn(II)-Schiff bases complexes ZnLa - ZnLc were prepared by direct reaction of the ligands La-Lc with Zn(II) ions in equimolar ratios bearing salicyldehydes with OH, NO2 and Cl functional groups. The synthesized compounds ZnLa - ZnLc were evaulated against Gram positive (Enterococcus faecalis NCIMB 13280, Streptococcus mutant ATCC 25175™ and Staphylococcus aureus ATCC 6538™) and gram negative (Escheria coli NCTC 12900, Salmonella typhi and Pseudomonas aeruginosa ATCC 15442) bacterial strains, respectively, by agar well diffusion and broth microdilution techniques. The minimum inhibitory concentration (MIC90) values were calculated by microplate reader at 550 nm to optimum result. It was found that all the synthesized compounds showed promising antibacterial activity against the genus Streptococcus mutant followed Staphylococcus aureus and Escheria coli. Binuclear Zn(II) complexes had a superior antibacterial activity compared to their parent Schiff base ligands. In general, 3,4-dihydroxy derived Schiff bases alongwith their relevant complexes exhibited magnificent antibacterial activity and hence merits to be established as promising keystone for subsequent antimicrobial drug advancement.
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