Recent advances in tissue engineering scaffolds based on polyurethane and modified polyurethane

Naureen, Bushra; Haseeb, A.S.M.A.; Basirun, Wan Jefrey; Muhamad, Farina

doi:10.1016/j.msec.2020.111228

Cited by 122 publications

(78 citation statements)

References 164 publications

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“…The major limitations are typically weaker cell adhesion compared to hydrogels based on natural polymers and the risk of the stimulation of a foreign body reaction by the polymer or its degradation products [ 2 , 124 ]. Synthetic polymers such as poly-L-lactic acid (PLLA) [ 155 , 156 ], poly(lactic-co-glycolic acid) (PLGA) [ 156 ], PCL [ 157 , 158 , 159 , 160 ], poly(ethylene glycol) (PEG) [ 161 , 162 , 163 ] and their copolymers [ 164 ], and various polyurethanes (PU) [ 165 , 166 , 167 , 168 ] are preferred for musculoskeletal tissue engineering. Among the synthetic polymers, elastomers, such as polydimethylsiloxane (PDMS), have been extensively used for the 2D fabrication of tissue-engineered muscle thin films due to their excellent biostability and tunable elasticity [ 169 , 170 ].…”

Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various cell types, signaling molecules, architectural cues, and physicochemical properties to be successful. To promote muscle repair and regeneration, various strategies for skeletal muscle tissue engineering have been developed in the last decades. However, there is still a high demand for the development of new methods and materials that promote skeletal muscle repair and functional regeneration to bring approaches closer to therapies in the clinic that structurally and functionally repair muscle. The combination of stem cells, biomaterials, and biomolecules is used to induce skeletal muscle regeneration. In this review, we provide an overview of different cell types used to treat skeletal muscle injury, highlight current strategies in biomaterial-based approaches, the importance of topography for the successful creation of functional striated muscle fibers, and discuss novel methods for muscle regeneration and challenges for their future clinical implementation.

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Section: Biomaterials For the Transplantation Of Striated Muscle Cellsmentioning

confidence: 99%

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Alarçin

Bal‐Öztürk

Avcı

et al. 2021

IJMS

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“…Scaffold materials mainly include inorganic materials, natural polymer materials and synthetic polymer materials. [14][15][16][17][18][19][20][21][22] Inorganic materials such as tricalcium phosphate, hydroxyapatite, coral and so on, which are generally only suitable for bone tissue engineering, are difficult to process and have high brittleness. 14,15 Natural polymer materials such as collagen, hyaluronic acid, chitosan and so on have uncontrollable degradation rate in vivo, poor strength and processing performance and bad batch repeatability.…”

Section: Introductionmentioning

confidence: 99%

Growth factor loading on aliphatic polyester scaffolds

Shen

2021

RSC Adv.

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“…Polyurethanes have proven to be interesting candidates for composite biomaterials used in vascular implants and grafts due to their biocompatibility with human body tissues [ 28 , 29 , 30 , 31 , 32 ]. In the same context, poly (ester-urethane)-containing phosphorylcholine segments have been shown to improve the hemocompatibility of blood-contacting medical devices [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

Anghel¹,

Dinu²,

Vereştiuc

et al. 2021

Polymers

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Designing composites based on natural polymers has attracted attention for more than a decade due to the possibility to manufacture medical devices which are biocompatible with the human body. Herein, we present some biomaterials made up of collagen, polyurethane, and cellulose doped with lignin and lignin-metal complex, which served as transcutaneous drug delivery systems. Compared with base material, the compressive strength and the elastic modulus of biocomposites comprising lignin or lignin-metal complex were significantly enhanced; thus, the compressive strength increased from 61.37 to 186.5 kPa, while the elastic modulus increased from 0.828 to 1.928 MPa. The release of ketokonazole from the polymer matrix follows a Korsmeyer–Peppas type kinetics with a Fickian diffusion. All materials tested were shown to be active against pathogenic microorganisms. The mucoadhesiveness, bioadhesiveness, mechanical resistance, release kinetic, and antimicrobial activity make these biocomposites to be candidates as potential systems for controlled drug release.

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Recent advances in tissue engineering scaffolds based on polyurethane and modified polyurethane

Cited by 122 publications

References 164 publications

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Current Strategies for the Regeneration of Skeletal Muscle Tissue

Growth factor loading on aliphatic polyester scaffolds

Transcutaneous Drug Delivery Systems Based on Collagen/Polyurethane Composites Reinforced with Cellulose

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