Recent advances in the development and administration of chemotherapy for malignant diseases have led to prolonged survival of patients and the promise of a return to normal lives. The cost of progress comes with a price, however, and the nervous system is frequently the target of therapy-induced toxicity. Unlike more immediate toxicities that affect the gastrointestinal tract and bone marrow, chemotherapy-induced neurotoxicity is frequently delayed in onset and may progress over time. In the peripheral nervous system, the major brunt of the toxic attack is directed against the peripheral nerve, targeting the neuronal cell body, the axonal transport system, the myelin sheath, and glial support structures, resulting in chemotherapy-induced peripheral neuropathy.
Objectives: To evaluate serum magnesium level in children with 3rd degree malnutrition and to compare these values with healthy children. Study Design: Cross sectional comparative study. Setting and Duration: Pediatric Department of Allied Hospital Faisalabad from Oct. 2003 to Nov. 2004. Subjects: Cases: 60 children of age six month to five year having weight < 60% of that for age. Control: 60 healthy children of age six month to five year having weight > 80% of that for age. Methods: Both cases & controls were selected from indoor & outdoor through simple random sampling. Detailed history & examination was done and S/Mg level were measured by atomic absorption spectrophotometer. Data was analyzed with the help of SPSS by applying T test and was presented by frequency tables. Results: The cases showed decreased S/Mg level (1.11+/- 0.24 mg/dl) as compared to controls (2.01+/- 0.78mg/dl).S/Mg levels were also decreased in cases with height < 80 % of that for age (0.98+/-0.5mg/dl) as compared to controls having height > 90 % of that for age. S/Mg levels were markedly low in cases who had low albumin level (0.98+/- 0.05 mg/dl) and those children who presented with persistent diarrhea (0.96+/-0.12mg/dl) Conclusion: S/Mg levels were decreased in children with PEM as compared to those with age and sex matched control. This decrease in S/Mglevels was marked in those cases who had decrease serum albumin level and persistent diarrhea.
Recent advances in the development and administration of chemotherapy for malignant diseases have led to prolonged survival of patients and the promise of a return to normal lives. This progress comes with a price, however, and the nervous system is frequently the target of therapy-induced toxicity. Unlike more immediate toxicities that affect the gastrointestinal tract and bone marrow, chemotherapy-induced neurotoxicity is frequently delayed in onset and may progress over time. In the peripheral nervous system, the major brunt of the toxic attack is directed against the peripheral nerve, targeting the neuronal cell body, the axonal transport system, the myelin sheath, and glial support structures, resulting in chemotherapy-induced peripheral neuropathy.
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