This study aimed to investigate the therapeutic effect of Medical Ozone(MO) in combination with insulin on reproductive hormones and histopathological changes in ovaries of rats with diabetes mellitus (DM). forty eight adult female rats were randomly divided into the following six groups (n = 8): control (A), MO (B), diabetic (C), MOtreated diabetic (E), Insulin-treated diabetic ) E), and MO, Insulin-treated diabetic (F). DM was induced by a single intraperitoneal (ip) Alloxan injection (150 mg/kg ( .after six weeks of treatment Blood sample were collected to estimate biochemical parameters glucose, serum hormones. Also, ovary samples were obtained for histological examination in diabetic untreated rats the results showed hyperglycaemia, and significant decrease in hormones profiles. While ,MO and Insulin treated rats reported an amelioration of the most toxic effect of alloxan and returned most of these parameters nearly normal. Microscopically ovaries showed definite, degeneration in the diabetic group while when use of MO and Insulin treatment in this study showed significant improves of such histological changes when compared to diabetic untreated rats. Conclusion: it was recommended that the use of the Medical Ozone with Insulin as a supplementary agent to reduce oxidative stress damage of hyperglycaemia and recommended to use variable doses and different periods of treatment to evaluate the best dose and period
Ivermectin (IVM) is a lipophilic anthelmintic drug widely used for the control of internal and external parasites in both human and veterinary medicin. This study aimed to investigate the effect of different dose of Ivermectin (IVM) on the Cortisol hormones (functionally and histologically) of twenty four of mature female rabbits in basrah. Animals were randomly divided into four groups (six for each). The first group was left without treatment (control group), second, third and fourth group treated weekly by injection s/c ivermectin for 8 week at dose (0.5mg, 1mg and 2 mg / kg.bw ) respectly .Results conducted to increase significant in cortisol concentration in fourth group ,while the first and second and third group did not affected when compared with fourth group or within them .The histopathological changes as a results of ivermectin treatment in adrenal there is representive by vacuolation of zona glomerulosa and zona fasculata in group fourth and less effect in other treatment. We concluded high dose of ivermectin and prolong period may affected on adrenal gland function.
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