Effect of Different Doses of Ivermectin on Biomarker Hormone of Adrenal Gland and Histology of It in Local Female Rabbits

Abstract

Ivermectin (IVM) is a lipophilic anthelmintic drug widely used for the control of internal and external parasites in both human and veterinary medicin. This study aimed to investigate the effect of different dose of Ivermectin (IVM) on the Cortisol hormones (functionally and histologically) of twenty four of mature female rabbits in basrah. Animals were randomly divided into four groups (six for each). The first group was left without treatment (control group), second, third and fourth group treated weekly by injection s/c ivermectin for 8 week at dose (0.5mg, 1mg and 2 mg / kg.bw ) respectly .Results conducted to increase significant in cortisol concentration in fourth group ,while the first and second and third group did not affected when compared with fourth group or within them .The histopathological changes as a results of ivermectin treatment in adrenal there is representive by vacuolation of zona glomerulosa and zona fasculata in group fourth and less effect in other treatment. We concluded high dose of ivermectin and prolong period may affected on adrenal gland function.