Introduction: Staphylococcus aureus is a chief source of both community and nosocomial infections. Isolates of Staphylococcal aureus from tertiary hospitals are resistant to frequently used antimicrobials. The intrinsically established methicillin-resistant S. aureus (MRSA) has been related with increased mortality and morbidity in hospital patients. Aim: This analysis was performed to determine the susceptibility of antibiotic pattern of staphylococcal aureus isolates with particular emphasis on methicillin-resistant S. aureus. Place and Duration: In the Department of Medicine and Pathology, Islam Medical and Dental College Sialkot for six-months duration from April 2021 to October 2021. Methods: Clinical samples from the Medicine ward were analysed and all isolates of S. aureus were involved in the study. Identification of isolates was done using a typical laboratory technique. The susceptibility antibiotic pattern of all strains of staphylococcal aureus was assessed using the improved Kirby Bauer method of antibiotic susceptibility. Results: Out of 120 isolates of S. aureus, MRSA were found to be in 29 (26.12%). The multidrug resistance percentage was 6.09% for MSSA and 75.86% for MRSA. All isolates of staphylococcal aureus were penicillin resistant. Though, sensitivity of all strains to vancomycin was noticed. Conclusions: This analysis exhibited an augmented incidence of MRSA in a Tertiary Care Hospital. Consistent investigation of nosocomial infections and susceptibility of antibiotics are essential to reduce the incidence of MRSA in hospitals and its spread in society. This study clearly demonstrates that the 1st line treatment for infection with MRSA is vancomycin. To maintain its worth, the usage of vancomycin must be restricted and only directed when clearly necessary. Keywords: MSSA, MRSA, Vancomycin, Antibiotic susceptibility and Staphylococcus aureus
Iron deficiency anemia is the most prevalent anemia type and is identified by the use of blood tests for iron levels. In iron deficiency anemia, reactive thrombocytosis is a common complication. The study's primary goal is to determine if there is a relationship between platelet and iron parameters in patients with iron deficient anemia. Place and Duration: This cross-sectional research was done among patients with iron deficiency anemia in the Department of Medicine and Pathology, Sharif Medical College, Lahore for one-year duration from January 2021 to December 2021. Method: This Observational research was conducted in the Department of Medicine and Pathology order to collect information. The platelet and iron parameters of 70 iron deficiency anemia patients were determined using blood samples taken from the patients. The data was analyzed with the help of SPSS version 20. Results: Patients with iron deficiency anemia were found to have thrombocytosis in 58 (82.9 percent) of the cases. When serum iron, percentage saturation, and platelet distribution were taken into consideration (all p0.001), platelet count was shown to be adversely connected to these variables, but a positive association was found between plateletcrit and platelet count (all p<0.05). There was a negative link between serum iron and plateletcrit (p<0.001) and PDW (p<0.05), but only a positive relationship was found with TIBC, mean platelet volume (p<0.05), and platelet (all p<0.05). There was a significant negative relationship between platelet count and mean platelet volume (p<0.001). Platelet and mean platelet volume correlated positively (p<0.05), while plateletcrit and mean platelet volume correlated negatively (p<0.05). Neither a correlation nor a non-correlation between iron parameters and mean platelet volume were discovered (p>0.05). Conclusion: When it comes to patients with iron deficient anemia, thrombocytosis is more prevalent than thrombocytopenia. The most critical factors impacting platelet count are serum iron and percentage saturation. Keywords: Hemoglobin, thrombocytosis and iron deficiency anemia.
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