A comprehensive review of the world literature confirms that malignant catatonia continues to occur and is reported and discussed in psychiatric community. It is associated with affective disorders as well as schizophrenia. The pathophysiology is still unclear but most reports suggest a hypodopaminergic state. Its reported mortality has declined from 75-100% in the preneuroleptic era to 31% during the review period (1986-1992). Bomocriptine, dantrolene, and benzodiazepines have been used with success but ECT has been found to be life-saving. The present review supports earlier reports that neuroleptics are frequently lethal in some patients with malignant catatonia.
| http://medcraveonline.com severity of these soldiers' war experiences was often overwhelming, and their substance use was one of much behaviour that led them to a rapid decomposition from their previous high level of functioning. The following soldier's case is representative of what I saw in many of these chronically ill veterans. Conflicts of interests Author declares that there is no conflict of interest.
THERE exist two apparently conflicting theories to explain the ratios of products accompanying reactions of bases with 2-halogenoalkanes, one based on steric requirements,l the other on the concept of a variable transition state.2 Recently it has become apparent that both steric and electronic factors may, under appropriate conditions, exert important directive effects. For example, in t-butyl alcohol, triethylmethanol, and toluene, the steric requirements of the base have been found to exert an important directive e f f e ~t , ~ while in tetrahydrofuran and dimethyl sulphoxide the effect of base size is of only minor importance.Sp4
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