Video abstractPoint your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use:https://youtu.be/Dk46ni8vjz4Introduction: Vitiligo is one of the most common hypomelanoses. Current treatments include ultraviolet, topical corticosteroids, calcineurin inhibitors. Orally administered vitamins, acting as anti-oxidants and in combination with ultraviolet light have also demonstrated skin repigmentation. In our pilot study of seven patients, we injected skin affected with vitiligo intradermally with a complex of vitamins and minerals and assessed the outcome. Aim: The aim of this study was to evaluate a novel treatment modality for vitiligo. Methods: We present a pilot study of seven patients; each having been diagnosed with generalized progressive vitiligo. In all cases, multiple therapies had been previously attempted. All patients were subjected to intradermal injections of biorevitalizant NCTF 135 (3 mls) in the hypo-pigmented areas of skin, once a week for 5 weeks. A 30Gx13 mm needle was used for the 0.025 mls intradermal injections to create micro-papules with a 1 cm distance between the injection sites. The results were assessed at 2 weeks and 5 weeks and were considered successful if partial or complete repigmentation was achieved.Results: Partial or complete skin re-pigmentation post-treatment was observed in vitiligo macules of all patients (100%). No significant side effects, or exacerbation of vitiligo were observed during or after treatment with NCTF 135 in the following 6 months (five patients) and 12 months (two patients). Discussion: Increasing the armamentarium of new treatments of vitiligo is important. Previous studies showed the effectiveness of oral and intramuscularly injected multivitamins in the treatment of vitiligo, explaining the results by the antioxidative qualities of the above.Our study demonstrated that intradermal mesotherapy injections of NCTF135, rich with vitamins and other antioxidants are well tolerated and effective in achieving significant repigmentation of de-pigmented skin in all patients studied, including five who had been resistant to previous standard therapies.
Flushing can occur as a physiological response or may indicate an underlying condition, such as carcinoid syndrome, mastocytosis or rosacea. The mechanisms and causes of flushing are discussed.Learning objective At the conclusion of this learning activity, participants should be able to describe the pathogenesis and clinical characteristics of flushing and should be aware of the modalities to diagnose and treat this common dermatological sign. © 1997 Elsevier Science B.V.
Key content Pregnancy results in various physiological skin changes. As a consequence, some common dermatoses can present more frequently in pregnant women. In addition, there are a number of skin eruptions unique to pregnancy. The aetiology of physiological skin changes in pregnancy is uncertain but is thought to be due to hormonal and physical changes of pregnancy. The four dermatoses of pregnancy are: atopic eruption of pregnancy, pemphigoid gestationis, polymorphic eruption of pregnancy and intrahepatic cholestasis of pregnancy. Learning objectives To understand the physiological skin changes in pregnancy. To identify the skin conditions that require appropriate referral. To be able to take a history, to diagnose the skin eruptions unique to pregnancy, undertake appropriate investigations and first‐line management, and understand the criteria for referral to a dermatologist.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.