Video abstractPoint your SmartPhone at the code above. If you have a QR code reader the video abstract will appear. Or use:https://youtu.be/Dk46ni8vjz4Introduction: Vitiligo is one of the most common hypomelanoses. Current treatments include ultraviolet, topical corticosteroids, calcineurin inhibitors. Orally administered vitamins, acting as anti-oxidants and in combination with ultraviolet light have also demonstrated skin repigmentation. In our pilot study of seven patients, we injected skin affected with vitiligo intradermally with a complex of vitamins and minerals and assessed the outcome. Aim: The aim of this study was to evaluate a novel treatment modality for vitiligo. Methods: We present a pilot study of seven patients; each having been diagnosed with generalized progressive vitiligo. In all cases, multiple therapies had been previously attempted. All patients were subjected to intradermal injections of biorevitalizant NCTF 135 (3 mls) in the hypo-pigmented areas of skin, once a week for 5 weeks. A 30Gx13 mm needle was used for the 0.025 mls intradermal injections to create micro-papules with a 1 cm distance between the injection sites. The results were assessed at 2 weeks and 5 weeks and were considered successful if partial or complete repigmentation was achieved.Results: Partial or complete skin re-pigmentation post-treatment was observed in vitiligo macules of all patients (100%). No significant side effects, or exacerbation of vitiligo were observed during or after treatment with NCTF 135 in the following 6 months (five patients) and 12 months (two patients). Discussion: Increasing the armamentarium of new treatments of vitiligo is important. Previous studies showed the effectiveness of oral and intramuscularly injected multivitamins in the treatment of vitiligo, explaining the results by the antioxidative qualities of the above.Our study demonstrated that intradermal mesotherapy injections of NCTF135, rich with vitamins and other antioxidants are well tolerated and effective in achieving significant repigmentation of de-pigmented skin in all patients studied, including five who had been resistant to previous standard therapies.
A study of different types of skin sensitivity in patients with keloid and hypertrophic scar tissues was conducted in order
to optimize clinical diagnostics of scar hypertrophy of the skin. A symmetrical area of unaffected skin was examined as
control. The revealed results suggest a sharp increase of deep skin sensitivity with simultaneous reduction of other types
of sensitivity, which was observed in 97% of subjects, as a new differential sign of keloid scar tissues.
Между патологическими кожными процессами, психическим состоянием и нарушениями гепатобилиарной системы существует тесная клиническая и филогенетическая связь. Представлено исследование сравнительной эффективности системной противогрибковой монотерапии препаратом тербинафин и его комбинации с адеметионином, гепатопротектором с антидепрессивной активностью, у больных (n=108) с верифицированным диагнозом онихомикоза, сочетанного с зудящими дерматозами. Отмечена успешность применения адеметионина с целью снижения риска гепатотоксичности, нормализации биохимических показателей и нервно-психического статуса.
BACKGROUND: Mycoses of the feet is a significant interdisciplinary health problem.
AIM: To analyze and systematize the causes contributing to the high incidence of foot mycoses in Russia.
MATERIALS AND METHODS: With the use of an anonymous questionnaire survey, the attitude of patients toward their health and the opinions of dermatologists and related specialists about the causes contributing to the high incidence of foot mycoses in the Russian population were analyzed.
RESULTS: The reasons contributing to the high incidence of foot mycoses in Russia are ranked into four groups: (1) depend on the activities of the dermatological service; (2) are related to the level of professional training of doctors of related specialties; (3) objective organizational reasons for doctors of related specialties; (4) depend on the patients attitude to their health.
CONCLUSION: The data obtained can be used to develop a complex of therapeutic and prophylactic measures to improve medical care for this contingent of patients.
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