Summary Background The aim of the study was to investigate the association of paraoxonase 1 (PON1) polymorphism, PON1/arylesterase (ARE) activity and oxidative stress index (OSI) in breast cancer (BC) patients with type 2 diabetes (DM). Methods Our study group consisted of 30 healthy women (HV group) and 66 female BC patients. The BC patients were divided into two groups: those with (n=37) and without DM (n=29) (BDM and NBDM group). Genotyping of PON1 Q192R and L55M polymorphisms were done by polymerase chain reaction (PCR) – restriction fragment length polymorphism (RFLP) method. Serum PON1/ARE enzyme activities, total oxidant status (TOS) and total antioxidant status (TAS) were analysed by spectrophotometric method. The ratio of TOS to TAS was accepted as the oxidative stress index (OSI). Results PON1 Q192R genotype frequency distribution was significantly different in the BDM group compared to the NBDM group (p=0.021). When alleles distribution was examined, R and L alleles were significantly lower, Q and M alleles were significantly higher in the BDM group than in the NBDM group (p<0.001). TOS and OSI were statistically higher in BC patients than HV group (p<0.001). Conclusions Our results suggest that PON1 gene Q and M alleles may be the risk factors predisposing formation of BC due to increased oxidant damage seen in DM. However, these statements require further confirmation with screening PON1 polymorphism in a greater number of patients with DM, and also wide range follow-up studies are necessary for the same purpose.
Aim: To retrospectively evaluate the results our pancreaticoduodenectomy surgeries in terms of morbidity and mortality rates as well as safety. Materials and methods: Medical records of 71 patients, who underwent pancreaticoduodenectomy surgery between examined retrospectively. Age, sex, the type and localization of the lesion, surgical properties and postoperative complications were studied. Results: A total of 71 patients (48 male, 23 female) with a mean age of 59.9 years who underwent pancreaticoduodenectomy were included in the study. Forty two patients (59%) had pancreatic head malignancies, 19 patients (27%) had ampulla malignancies, 4 patients (5.5%) had duodenum malignancies and 4 patients (5.5%) had common bile duct malignancies. Two of our cases (3%) underwent surgery for pancreatitis. Surgery related mortality rate was 2.8% (2 cases). The most frequently encountered complications were delay in gastric emptying (19%), pancreatic fistula (14%) and wound infection (10%). Postoperative morbidity rate was detected to be 28%. Conclusion: Pancreatic and other periampullary tumors are serious clinical problems that cause morbidity. Traditionally, these patients have a dark prognosis but correct staging and appropriate patient selection allow better results. Surgical resection, the one reason for long-term survival, should be preferred whenever possible. In conclusion, we have found out that pancreaticoduodenectomy surgery is an effective and safe surgical method in the treatment of pancreas and common bile duct problems. This surgical procedure can be performed with low morbidity and mortality rates in experienced but low-density centers. Pankreatikoduodenektomi Operasyonu Sonuçları: 71 Olguluk Tek Merkez Deneyimi Özet Amaç: Kliniğimizde gerçekleştirilen pankreatikoduodenektomi operasyonu sonuçlarının morbidite ve mortalite hızları ve güvenilirlik açısından retrospektif olarak değerlendirilmesi. Gereç ve Yöntemler: Ocak 2007-Eylül 2012 tarihleri arasında Kocaeli Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı'nda Whipple operasyonu yapılan 71 hastanın dosya kayıtları morbidite, mortalite ve güvenilirlik açısından geriye dönük olarak incelenmiştir. Yaş, cinsiyet, lezyon tipi ve lokalizasyonu, cerrahi özellikler ve postoperatif komplikasyonlar kaydedildi. Bulgular: Ortalama yaşı 59.9 yıl olan ve pankreatikoduodenektomi uygulanan 71 hasta (48 erkek, 23 kadın) çalışmaya dahil edildi. Kırkiki olgu (%59) pankreas başı, 19 olgu (%27) ampulla, 4 olgu (%5,5) duodenum, 4 olgu (%5,5) koledok malignitesine sahip idi. İki olguya ise (%3) pankreatit nedeniyle cerrahi uygulandı. Cerrahiye bağlı mortalite oranı %2,8 (2 olgu) idi. En sık rastlanan postoperatif komplikasyonlar; mide boşalımında gecikme (%19), pankreas fistülü (%14) ve yara enfeksiyonu (%10) idi. Postoperatif morbidite oranı ise %28 olarak saptandı. Sonuç: Pankreas ve diğer periampuller bölge tümörleri ciddi morbiditeye neden olan klinik problemlerdir. Geleneksel olarak bu hastalar karanlık bir prognoza sahip olmakla birlikte, doğru evreleme ve uygun has...
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