Association of serum paraoxonase 1 activities, polymorphisms and oxidative stress in breast cancer patients with type 2 diabetes mellitus

Eraldemir, Fatma Ceyla; Üren, Nihal; Kum, Tuğba; Erbay, Burcu; Şahin, Deniz; Acar, Esra; Özsoy, Doğa; Çekmen, Mustafa; Kır, Hale Maral; Utkan, Zafer

doi:10.2478/jomb-2018-0043

Cited by 11 publications

(5 citation statements)

References 21 publications

(27 reference statements)

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“…On the other hand, the QR genotype was more common in the control group compared with patients with nasal polyps. The distribution of the genotype in the control group of the study by Eraldemir et al [ 28 ] is compatible with our results. The major limitation of this study is the lack of information about the PON1 enzyme levels and activities in our study group.…”

Section: Discussionsupporting

confidence: 93%

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Avcıkurt

Gençer

Yazıcı

2020

J Biochem & Molecular Tox

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The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal‐polyp disease. The study examined 62 nasal‐polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction‐restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal‐polyp patients (QQ = 69.35%, QR = 25.81%, RR = 4.83%) and healthy controls (QQ = 52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal‐polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.

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Section: Discussionsupporting

confidence: 93%

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Avcıkurt

Gençer

Yazıcı

2020

J Biochem & Molecular Tox

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“…(3) show a highly significant increase (p≤ 0.01) in this index in serum and saliva of the pre-malignant and malignant breast tumor patient groups compared to the corresponding value in the control group. These results agree with the results of Feng et al, 2012 in China [18] and Eraldemir, 2019 in Turkey [20] reporting the presence of a high value of OSI in serum of studied breast cancer women with type 2 diabetes mellitus who underwent surgery compared to the control group This index was also observed to increase significantly (p≤ 0.01) in saliva and serum samples from women with breast cancer compared to the corresponding fluid from the premalignant (benign) group, a result that was in agreement with the result of the Sawczuk et al 2019 study that reported an elevated [OSI] in saliva from women with malignant tumor with and without mutation in BRCA1, (BRCA1 encodes a suppressor protein) [21]. As the disease progressed from pre-malignant to malignant stages, significant differences were observed among the three study groups as illustrated in Fig.…”

Section: Methodssupporting

confidence: 93%

Redox status in saliva and serum of Iraqi patients in a pre-malignant and early malignant stage of breast tumors

Jabar,

Hathama Razooki Hasan

2023

Iraqi j. cancer med. genet.

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Breast cancer, as is commonly assumed, one of the most diagnosed kind of cancer is a multifactorial disease, its exact cause is still unknown. It is considered the second killer cancer among women. The present study participants were Iraqi women patients in pre-malignant and malignant (n=59) women with breast tumors as well as age matched healthy Iraqi women (n=27). This study aimed to evaluate the redox status upon transformation from premalignant (benign) to malignant stage of breast cancer by evaluating the saliva-blood correlation to look for the possibility using saliva as alternative fluid for diagnosis of the tumor stages. This was achieved by measuring the [total oxidant status level (TOS), total antioxidant status level (TAS), and oxidative stress index level(OSI). (TOS) and (TAS) were determined in saliva and serum fluid samples from all participants using colorimetric methods, while the oxidative stress index (OSI) was calculated. The results obtained from the study showed that the P value ≤ 0.01 significantly increased the measured [TOS] level and the calculated [OSI] level in saliva and serum fluid samples in contrast significantly decreased the P value ≤ 0.01 in the [TAS] level in both types of fluids of the patient groups compared to that of the healthy control group. Similar results were obtained when the values of these parameters were compared in both samples (serum and saliva) samples were compared between the patient groups in both breast tumors (Pre-malignant& malignant).

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“…24 Changes in PON1 activity attributed to the Q192R polymorphism can have a significant effect on oxidative conditions and disease exacerbation in individuals. 25 A study by Ferré et al showed that PON-192 polymorphism, along with other polymorphisms, contributes to changes in the host response to HCV infection. 26 Taken together, allelic frequency as well as the effects of ethnicityrelated factors on the PON1 activity may, at least in part, explain the differences in mortality and the prevalence of COVID-19 between various countries.…”

Section: Discussionmentioning

confidence: 99%

“…24 Changes in PON1 activity attributed to the Q192R polymorphism can have a significant effect on oxidative conditions and disease exacerbation in individuals. 25…”

Section: Discussionmentioning

confidence: 99%

Paraoxonase 1 rs662 polymorphism, its related variables, and COVID-19 intensity: Considering gender and post-COVID complications

Ghoreshi

Abbasi-Jorjandi

Asadikaram

et al. 2022

Exp Biol Med (Maywood)

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In this study, we aimed to investigate the effect of paraoxonase 1 (PON1) rs662 polymorphism, arylesterase (ARE) activity, and the serum lipid profile in patients with coronavirus disease 2019 (COVID-19) in different stages of the disease considering post-COVID outcomes. A total of 470 COVID-19 patients (235 female and 235 male patients) were recruited into the study, and based on the World Health Organization (WHO) criteria, the patients were divided into three groups: moderate, severe, and critical. PON1 rs662 polymorphism was determined by the Alw 1 enzyme followed by agarose gel electrophoresis. Moreover, serum levels of triglycerides (TG), cholesterol (Chol), high-density lipoprotein–cholesterol (HDL-c), and low-density lipoprotein–cholesterol (LDL-c), as well as the level of the ARE activity of PON1 in the sera of patients were measured at the time of infection and one and three months after hospitalization. There was a significant relationship between the G allele and the severity of the disease. In addition, the probability of death in homozygous individuals (GG) was higher than in heterozygous patients (GA), and it was higher in heterozygous patients than in wild-type individuals (AA). There was also a significant relationship between the decrease in serum lipids and the intensity of COVID-19. On the contrary, at the onset of the disease, the HDL-c level and serum ARE activity were reduced compared to one and three months after COVID-19 infection. The findings of this study indicated the significant impact of PON1 rs662 polymorphism on ARE activity, lipid profiles, disease severity, and mortality in COVID-19 patients.

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Association of serum paraoxonase 1 activities, polymorphisms and oxidative stress in breast cancer patients with type 2 diabetes mellitus

Cited by 11 publications

References 21 publications

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Redox status in saliva and serum of Iraqi patients in a pre-malignant and early malignant stage of breast tumors

Paraoxonase 1 rs662 polymorphism, its related variables, and COVID-19 intensity: Considering gender and post-COVID complications

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