Background: Around one in ten adults take antidepressants for depression in England, and their long-term use is increasing. Some need them to prevent relapse, but 30-50% could possibly stop them without relapsing and avoid adverse effects and complications of long-term use. However, stopping is not always easy due to withdrawal symptoms and a fear of relapse of depression. When general practitioners review patients on long-term antidepressants and recommend to those who are suitable to stop the medication, only 6-8% are able to stop. The Reviewing long-term antidepressant use by careful monitoring in everyday practice (REDUCE) research programme aims to identify safe and cost-effective ways of helping patients taking long-term antidepressants taper off treatment when appropriate.
Edward Palmer (E. P.) Thompson was a historian, dissident communist, and peace activist. One of the English‐speaking world's finest social historians and a lifelong campaigner for human rights and critic of powerful elites, he fits easily in few preconceived understandings of radicalism. Reared in a household steeped in the proselytizing zeal of Methodist missionaries, Thompson himself was a dissident atheist. With an American mother and an English father, his origins were unmistakably internationalist, yet he would often mistakenly be associated with a narrow parochialism.
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