OBJECTIVE:To examine the impact of important weight loss on insulin inhibition of its own secretion during experimentally induced hyperinsulinemia under euglycemic conditions. DESIGN: Longitudinal, clinical intervention studyFbariatric surgery (vertical banded gastroplastyFgastric bypassFCapella technique), re-evaluation after 4 and 14 months. SUBJECTS: Nine obese patients class III (BMI ¼ 54.672.6 kg/m 2 ) and nine lean subjects (BMI ¼ 22.770.7 kg/m 2 ). MEASUREMENTS: Euglycemic hyperinsulinemic clamp (insulin infusion: 40 mU/min m 2 ), C-peptide plasma levels, electrical bioimpedance methodology, and oral glucose tolerance test (OGTT). RESULTS: BMI was reduced in the follow-up: 44.572.2 and 33.971.5 kg/m 2 at 4 and 14 months. Insulin-induced glucose uptake was markedly reduced in obese patients (19.571.9 mmol/min kg FFM) and improved with weight loss, but in the third study, it was still lower than that observed in controls (35.974.0 vs 52.972.2 mmol/min kg FFM). Insulin-induced inhibition of its own secretion was blunted in obese patients (19.975.7%, relative to fasting values), and completely reversed to values similar to that of lean ones in the second and third studies (À60.874.2 and À54.076.1%, respectively). CONCLUSION: Weight loss in severe obesity improved insulin-induced glucose uptake, and completely normalized the insulin inhibition on its own secretion.
Reno BA et al. Neo-omphaloplasty in anchor-line abdominoplasty performed in patients who have previously undergone bariatric surgery Neo-onfaloplastia no decurso das abdominoplastias em âncora em pacientes pós-cirurgia bariátrica
The correction of delayed deformities of the abdominal wall after mammary reconstruction with bipedicled TRAM flaps using double mesh was carried out in an effective and secure way, providing an interesting surgical option for mastologists and plastic and general surgeons.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.