2003
DOI: 10.1038/sj.ijo.0802269
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Restored insulin inhibition on insulin secretion in nondiabetic severely obese patients after weight loss induced by bariatric surgery

Abstract: OBJECTIVE:To examine the impact of important weight loss on insulin inhibition of its own secretion during experimentally induced hyperinsulinemia under euglycemic conditions. DESIGN: Longitudinal, clinical intervention studyFbariatric surgery (vertical banded gastroplastyFgastric bypassFCapella technique), re-evaluation after 4 and 14 months. SUBJECTS: Nine obese patients class III (BMI ¼ 54.672.6 kg/m 2 ) and nine lean subjects (BMI ¼ 22.770.7 kg/m 2 ). MEASUREMENTS: Euglycemic hyperinsulinemic clamp (insuli… Show more

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Cited by 12 publications
(7 citation statements)
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References 41 publications
(39 reference statements)
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“…Biliopancreatic diversion, a bariatric surgical intervention inducing weight loss mainly by a malabsorptive mechanism, leads to an improvement of insulin resistance which overcomes the extent due to the reduction of body weight (20). This effect is different from the one produced by gastric bypass, which, in normoglycemic subjects, increases insulin sensitivity mainly, but not exclusively, in function of the weight, as indicated by other authors (20,21) and confirmed by the present study. It would be of great interest to investigate the cardiac autonomic regulation in patients who underwent a biliopancreatic diversion, to confirm the independent post-op evolution of insulin sensitivity and cardiac autonomic function.…”
Section: Analysis Of Covariancesupporting
confidence: 82%
“…Biliopancreatic diversion, a bariatric surgical intervention inducing weight loss mainly by a malabsorptive mechanism, leads to an improvement of insulin resistance which overcomes the extent due to the reduction of body weight (20). This effect is different from the one produced by gastric bypass, which, in normoglycemic subjects, increases insulin sensitivity mainly, but not exclusively, in function of the weight, as indicated by other authors (20,21) and confirmed by the present study. It would be of great interest to investigate the cardiac autonomic regulation in patients who underwent a biliopancreatic diversion, to confirm the independent post-op evolution of insulin sensitivity and cardiac autonomic function.…”
Section: Analysis Of Covariancesupporting
confidence: 82%
“…This change has been observed after diet and some bariatric procedures [22]. Pereira et al [23] described this phenomenon in nine patients at 6 and 14 months after undergoing verticalbanded gastroplasty-gastric bypass procedure. Jimenez et al [24] observed a normalisation of the insulin response at 3and 12 months following vertical gastroplasty, and Letiexhe et al [25] reported a similar finding in 12 obese non-diabetic subjects at 8 months after vertical-banded gastroplasty.…”
Section: Discussionmentioning
confidence: 94%
“…Other studies which also has glycemic control are as follows. 1,2,4,6,[8][9][10]12,14,[16][17][18][19]21,22 Type of surgery in DM in 65% SG was done & in 35%. RYGB was done with similar result in glycemic control in both surgeries.…”
Section: Discussionmentioning
confidence: 99%