Background: It has long been established that obesity plays a positive role against osteoporosis (OP) and lowimpact fractures (Fx). However, more recent data has shown higher fracture risk in obese individuals. The aim of this study was to investigate the association between BMI, particularly obesity, OP and low-impact Fx in Brazilian women, as well as to evaluate the SAPORI (Sao Paulo Osteoporosis Risk Index) tool performance to identify low BMD according BMI category. Methods: A total of 6182 women aged over 40 years were included in this cross-sectional analysis using data from two large Brazilian studies. All participants performed hip and spine bone mineral density (BMD) measurements and answered a detailed questionnaire about the presence of clinical risk factors (CRFs) related to low BMD and risk fractures. The World Health Organization (WHO) criteria were used to define obesity. Results: Age-adjusted osteoporosis prevalence was 20.8, 33.6, 47 and 67.1% in obese, overweight, normal and underweight category, respectively. Obesity was present in 29,6% (1.830 women) in the study population and the likelihood of osteoporosis and low-impact Fx compared to a normal BMI in this subgroup was of 0.24 (95% CI 0.20-0.28; p < 0.001) and of 1.68 (95% CI 1.35-2.11; p < 0.001), respectively. However, the hip Fx likelihood was lower in obese compared with non-obese women (OR = 0.44; 95% CI 0.20-0.97). Using an originally validated cutoff , the SAPORI tool sensitivity was significantly hampered in overweight and obese women although the accuracy had remained suitable because of increasing in specificity. Conclusions: The osteoporosis prevalence reduced as BMI increased and obesity was associated with low-impact Fx, regardless of the BMD measurements. Moreover, the SAPORI performance was impaired in obese women.
BACKGROUNDMelioidosis is an emerging infectious disease in Brazil caused by exposure to water or soil contaminated by the bacteria Burkholderia pseudomallei. Its clinical presentation is diverse, ranging from uncomplicated soft tissue infections to severe pneumonia and sepsis. Musculoskeletal involvement (4 to 12%) is often associated with systemic manifestations, mainly affecting lower limbs.
BACKGROUNDSystemic lupus erythematosus (SLE) is a multisystemic autoimmune disease. About 40% of patients have gastrointestinal tract involvement. Protein-losing enteropathy (PPE) is a rare manifestation that in half of the cases manifests as diarrhea. Usually in young women and is characterized by the appearance of edema and hypoalbuminemia in the absence of proteinuria in the nephrotic range. Enteropathy may clinically manifest with edema or cavity effusions, depending on serum albumin levels. Other symptoms that may be present are: nausea, vomiting and abdominal pain.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.