Background: Integrity of hemoglobin is a crucial determining factor for the overall health functions. Nutrient repletion therapy should be a fundamental strategy to restore the healthy properties of blood. A unique patent-pending iron-free VMP35 formulation was engineered by our laboratory to restore iron-dependent hemoglobin in anemic cells using a proprietary Prodosome® absorption technology. This formulation, containing an array of nano-emulsified botanical ingredients rich in bioflavonoids, strengthens the structural integrity of connective tissues, and potentiates immune competence, cellular aerobic metabolism, and enhances efficient regulation of inflammatory events. We discuss the intricate aspects of strong vs. fragile immunity and consequential inflammatory responses to convey a deeper understanding of the varied and overly complex sequela of immunological behaviors and events. The effect of the VMP35 is mediated through highly absorbable nutritional/nutrigenomic repletion enabling improvements in the systemic set of functional behaviors. In fact, the iron-free VMP35 facilitates a “Systems Biology Approach” which restores hemoglobin status, reverses anaerobic hypoxia, improves competent immune responsivity, and regulates appropriate and controlled activation of inflammatory sequela. Under these pathogenic circumstances, iron-deficiency anemia has been misconceptualized, and a new nosological term, Chronic Anemia Syndrome, is proposed. The comparative therapeutic rationale of Reductionist vs. Systems Biology approaches is also explained in detail. Methods: The efficacy of the novel therapeutic iron-free VMP35 liquid nutraceutical is detailed in restoring iron-dependent hemoglobin to RBCs and boosting cellular morphology, viability, and immune competence, thereby reducing the need for prolonging inflammatory sequela. Results: This was demonstrated in a previous IRB approved multi-subject human study. In addition, two recent case studies report dramatic restorative benefits of nutrient repletion therapy of the VMP35 on subjects having experienced near-fatal events, which confirmed the findings explained in this manuscript. Conclusions: This novel iron-free VMP35 modulates an array of homeostatic biological parameters such as enhanced hemoglobinization, aerobic metabolism, viral immuno-competence, and inflammatory regulation. Further research, examining mechanistic and beneficial effects in athletic performance, is in progress. Importantly, during these troubled immune challenging times, modulating an array of homeostatic immunological and inflammatory dysfunctions are tantamount to improved population outcomes. Trial Registration: The Clinical investigation in a total of 38 subjects was conducted under an Institutional Review Board (IRB) from the Path Foundation in New York, NY (#13-009 April 25, 2013). The two case studies were done at Lancaster General Hospital, Lancaster, PA, and Jefferson University Hospital, Philadelphia, PA, USA. Both studies were retrospectively registered.
Obesity and overweight are now defined as an epidemic. An array of evidence substantiates that existing weight loss strategies and programs have not worked. Fat is the lightest of macromolecules, the highest energy reserve of the body, and the last reservoir of survival insurance to be expended. Conventional weight loss concepts and therapies, for the most part, are based on two primary factors; people eat too much and don’t exercise enough. However, with the increase in gym memberships there has also been a significant increase in the purchase of more wholesome foods. The trajectory of obesity therefore should be decreasing; but it’s not. Furthermore, even the culturally ingrained term “weight loss” itself establishes “heaviness” as the primary criteria for evaluating body composition and size, i.e., scale weight, an inaccurate and erroneous measuring criterion owing to additional variables. An additional 10 factors that contribute to a reduction in metabolic rate and an increase in fat storage have been identified. Individually or in combination, these factors are almost totally ignored or omitted from considerations regarding the etiology of obesity. We developed TrimRox, a stimulant‐ and sugar‐free Prodosomed® TRCAP21 nutraceutical technology, utilizing six standardized extracts comprising of D‐ribose nicotinamide complex, Gynostemma pentaphyllum leaf extract, Myrciaria Dubia whole‐berry extract, Ilex guayusa Loes. (Guayusa) leaf extract, Purple Tea Camellia sinensis extract (PurpleForce™), and alpha Glyceryl phosphoryl choline that effectively addresses all the contributing factors. A 21‐day concept validation physician‐supervised pilot study on the TRCAP21 was conducted in 9 subjects to assess changes in various body parts, including chest, upper arms, waist/belly, hips, and thighs, as well as body weight. The results demonstrated that all subjects experienced a significant reduction in size of one or more of these body parts and significant reduction in body weight. A randomized double‐blind placebo‐controlled study is in progress.
Objectives NHLBI announced that anemia is one of the most common blood disorders, which affects more than 3 million Americans, while the Global Burden of Disease 2016 reported that anemia affects 1.93 billion people worldwide. Anemia is associated with chronic inflammatory conditions and autoimmune disorders. Hemorrhagic anemia results in substantial loss of blood with significant alterations in all blood parameters, including reduced iron. Another type of anemia is chronic anemia syndrome, which is a comprised of disorders in conjunction with chronic inflammation induced by an escalated anaerobic/acidic environment inducing a defensive expenditure of alkalinizing buffers in hemoglobin (i.e., histidine), to prevent a dangerous lowering of blood pH. Subsequently, iron is cleaved from heme groups, and transferred out of blood circulation into other organs, like the liver, appearing to be IDA, where excessive accumulation can lead to hemochromatosis, aka ‘iron overload anemia’. An orally consumed liquid iron-free VMP35 Multi-nutrient complex exhibited to restore iron-dependent hemoglobin to RBCs. Methods A randomized controlled one-way cross-over clinical investigation was conducted in 38 subjects (age: 12–82) to assess the rate of absorption and effects on blood following administration of a VMP35, a non-iron containing liquid nutraceutical supplement. After taking a baseline blood sample at 0 min, subjects consumed and held in the mouth for 30 seconds, either placebo or VMP35 (30 ml) after which blood was taken at 5 min and/or 30 min. Changes in peripheral blood smears were evaluated using live blood cell imaging with phase contrast microscopy. Furthermore, three case studies were conducted. Results VMP35 caused remarkable changes in the blood including morphological, hematological (including restoration of hemoglobin) and rheological changes following 5 min of administration, which sustained for at least 30 min. Results of the three case studies were very encouraging. Conclusions VMP35 restored the blood properties including restoring iron-dependent hemoglobin and potential benefits for subjects with compromised digestive systems without any adverse events. Three case studies provided strong confirmation of these therapeutic benefits to promote hematological integrity and rheology. Funding Sources VNI Inc, Lederach, PA, funded this study.
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