Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis

Downs, Bernard W.; Bagchi, Manashi; Morrison, Bruce S.; Galvin, Jeffrey; Kushner, Steve; Bagchi, Debasis

doi:10.1201/9780429438004-8

Cited by 3 publications

(7 citation statements)

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“…[160][161][162] Hypokalemia, a physiological condition of low potassium level, causes diverse adverse effects. [161][162][163] Although no signs and symptoms are observed in mild hypokalemia, moderate hypokalemia causes muscle weakness, fatigue and cardiovascular arrhythmias, while fatal heart attack can result from extreme hypokalemia. It has been reported that several blood pressure and cardiovascular medications including enalapril, captopril and lisinopril, irbesartan, valsartan, and angiotensin receptor blockers, can significantly raise the blood potassium level.…”

Section: Potassium (As Potassium Citrate)mentioning

confidence: 99%

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Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Downs¹,

Banik²,

Bagchi

et al. 2021

AJBPS

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An increase in anaerobic (oxygen-deprived) pathogenesis significantly increases the generation of reactive oxygen species (ROS) inflicting damage on cell membranes and intracellular constituents. Generation of ROS and concomitant inflammatory response is the two hallmarks of cellular damage caused by cellular injury or invasion by pathogens. Oxygen deprivation, as opposed to oxygen deficiency, is a major contributor to oxidative stress and damage, cytokine production, and inflammation. When our cells are unable to efficiently and effectively utilize the oxygen to facilitate aerobic glycolysis and other cellular metabolic events, the oxygen instead oxidizes cell membranes, lipids, neurons, cross-links proteins, damages DNA, and initiates inflammation among other consequences. These anaerobic events are hallmarks of chronic degenerative diseases (CDD). Excessive demands to curtail oxidative damage can overburden endogenous antioxidative capabilities. A key treatment strategy to tackle the adverse effects of inflammation involves the augmentation of the structural integrity and functional competence of cellular materials, reducing the impact and consequences of tissue insult; the generation of ROS; and the cascade of subsequent pathological disorders. Moreover, restoration of cellular aerobic metabolic events, such as aerobic glycolysis and oxidative respiration, is an equally important collateral goal. A healthy diet and supplementation, providing an abundance of exogenous sources of antioxidants and a host of phytochemical dietary components, becomes even more important to restore aerobic metabolism; augment and assist in improving cellular structural integrity, and thereby reducing oxidative stress, damage, and inflammatory sequela. VMP35 MNC, a research-affirmed Prodosomed nutraceutical technology-based phytonutrient formulation, enriched in structurally diverse bioflavonoids, polyphenols, and phenolic saccharides, etc., have been shown to boost cellular structural integrity and physiological functions, and restore aerobic metabolic competence including for athletic performance as well as for general well-being. This review provides a strategic approach for the design of a novel Prodosomed VMP35 Multinutrient/phytoceutical complex and to evaluate its ability to reverse anaerobic pathologies, including inflammation, and restore healthy cellular aerobic glycolysis.

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Section: Potassium (As Potassium Citrate)mentioning

confidence: 99%

“…Essential for lipid, fat, and carbohydrate metabolism 6. Lowers blood cholesterol Potassium [160][161][162][163] Potassium citrate 1. Boosts energy level and diverse physiological functions 2.…”

Section: Micronutrients and Macronutrients Constituents Physiological Performance And Metabolic Functionmentioning

confidence: 99%

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Downs¹,

Banik²,

Bagchi

et al. 2021

AJBPS

Self Cite

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“…Phytonutrients [18][19][20][21] Astragalus membranaceus [18][19][20][21] Vitamins a minimum of 85% non-GMO phosphatidylcholine, and subsequently impregnated and saturated the phospholipids with solar-dried electrolytes to ensure the enhanced availability of free ions, which will amplify the ionic properties of the multi-lamellar clustoidal phospholipid spheres, resulting in a net negative charge. e second step consists of thorough blending of a combination of researchaffirmed botanicals containing structurally diverse natural polyphenolic antioxidants, multivitamins, micro-and macronutrients, and naturally occurring phytonutrients, utilizing an advanced wet milling technology to create a nano-emulsion.…”

Section: Chemical Constituents Physiological Benefitsmentioning

confidence: 99%

“…e final step consists of a combination of a specific blending sequence and an encapsulation technology to obtain the patent pending multi-lamellar energetically fortified clustoidal "Prodosomal" liposome-type encapsulated supplement (VMP35 Prodovite ® ). [18][19][20][21][22]…”

Section: Chemical Constituents Physiological Benefitsmentioning

confidence: 99%

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Assessment of a Novel Bioflavonoids and Phytonutrient Formulation in Enhancing Cellular Aerobic Glycolysis, Immunity, Sports Performance, and Mitigating Inflammation

Downs¹,

Banik²,

Bagchi

et al. 2021

AJBPS

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Metabolic competence in conjunction with well-balanced nutritional support is extremely important for normal biochemical and physiological functions, as well as for enhanced athletic performance. Research-affirmed nutraceuticals enriched in structurally diverse phytonutrients including bioflavonoids may help to boost athletic, functional, and biophysiological competence. Occurrence of chronic degenerative disorders is associated with an increase in anaerobic events, namely, the inability to effectively use oxygen and water, and inability to use nutrients for cellular energy production and management, metabolic homeostasis, and waste removal. Earlier clinical studies in our laboratories using the WADA compliant bioflavonoid-enriched Prodosomed VMP35 Multinutrient Complex (“Prodovite®”) demonstrated that it boosted aerobic metabolic competence and provided protection against diverse chronic degenerative anaerobic disorders. We hypothesized that Prodosomed VMP35 may serve as a novel supplement to boost athletic performance. The objective of the study was to conduct selected focused pilot studies to demonstrate the efficacy of a WADA compliant Prodosomed VMP35 to improve athletic competence and performance in a variety of sports activities. The efficacy of VMP35 was assessed in different models of sports performance/athletic competence including power lifting, resistance training, cycling, and selected case studies. VMP35 supplementation restored aerobic metabolic events, minimized oxidative stress, and improved athletic performance, recovery, and immune competence. These pilot clinical studies demonstrate that iron-free VMP35 restores aerobic metabolism by restoring iron-dependent hemoglobin to red blood cells, bolstering neutrophils in the blood (immune support), and significantly improving performance output in a diverse range of athletic activities.

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Phytochemical analysis and anti-diarrhoea potential of ethanol leaves extract of Nypa frutican in albino rats

et al. 2023

Int. J. Adv. Biochem. Res.

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Diarrhoea is a leading cause of morbidity and mortality in children under the age of 5 years. Health Organization has encouraged studies that will bring about the desired treatment and prevention of diarrhoea. Nypa frutican commonly known as Nipa palm or Mangrove palm is used in traditional medicine for the treatment of various ailments and the leaves are locally used for making roofing mats, hats and brooms. This study was designed to evaluate the phytochemical constituents using Gas Chromatography-Flame Ionization Detector and anti-diarrhoea potential of ethanol leaves extract of Nypa frutican in albino rats. Fecal count, measurement of gastrointestinal charcoal meal distance and intestinal fluid electrolyte concentrations procedures were used. The quantitative phytochemical analysis revealed the presence of flavonoids, alkaloids, cyanogenic glycosides, oxalate, saponin, steroids, cardiac glycoside and tannin (35.53, 30.55, 16.88, 10.31, 9.79, 8.71, 4.86 and 1.95) µg/ml respectively. Extract of the leaves of Nypa frutican (200, 300 and 400) mg/kg in comparison with 5 mg/kg standard drug (loperamide hydrochloride), inhibited the production of diarrhoea stool, degree of gastrointestinal motility, and inhibited the concentration of intestinal fluid electrolyte (Na + , K + , Cland HCO3 -). The result obtained showed that ethanol leaf extract of Nypa frutican may contain some pharmacologically active substance with anti-diarrhoea potentials due its phytochemical components.

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Development and Utilization of a Novel Prodosomed-Electrolyte and Phytochemical Formulation Technology to Restore Metabolic Homeostasis

Cited by 3 publications

References 1 publication

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Design of a Novel Bioflavonoid and Phytonutrient Enriched Formulation in Boosting Immune Competence and Sports Performance: A product Development Investigation

Assessment of a Novel Bioflavonoids and Phytonutrient Formulation in Enhancing Cellular Aerobic Glycolysis, Immunity, Sports Performance, and Mitigating Inflammation

Phytochemical analysis and anti-diarrhoea potential of ethanol leaves extract of Nypa frutican in albino rats

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