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The results of the development of expected recovery curves for an empirically driven patient profiling system are presented. Patients undergoing a course of psychotherapy (N = 11 492) repeatedly took the Outcome Questionnaire-45 (OQ-45). Scores across all patients were combined into an aggregate dataset for use in generating expected recovery curves based on severity of symptoms at intake. SAS PROC MIXED was used to create a mixed linear model of recovery curves based on OQ-45 scores across sessions and the log transformation of session number. Mean estimates were established for each session from one to 20. Tolerance intervals were then created around each estimated mean score. Expected recovery curves were combined with tolerance intervals to create an early warning system capable of identifying patients whose slow progress suggests that they might be expected to have a negative therapy outcome (terminate treatment prior to obtaining a clinically significant benefit). Current efforts to establish a systematic quality improvement procedure using these curves are discussed. Charts of expected recovery values are plotted, and a straightforward system of patient profiling, early identification of treatment failures, and feedback to clinicians is described.

Mandibular growth retardation, coupled with relative macroglossia in E14 Dmm/Dmm mice, suggests that the concerted development of the palate and lower jaw complex in the mutant is aberrant. Detection of micrognathia and pseudomacroglossia in homozygotes, before the time of palate closure, supports the hypothesis that a relationship exists between growth retardation of Meckel's cartilage and malformation of the secondary palate, as predicted by the Pierre-Robin sequence.

Aim  Western mosquitofish (Gambusia affinis) have been linked with the decline of native fish and amphibians throughout the world. Separation along the temperature niche axis may promote the long‐term coexistence of introduced western mosquitofish, with native species in temperate regions. Recent research has shown that western mosquitofish can reduce the recruitment of native least chub (Iothichthys phlegethontis) endemic to the Bonneville Basin. We tested the hypotheses that cold temperatures (≤ 15 °C in the summer, freezing winters) would: (1) reduce the aggressive and predatory effects of western mosquitofish on least chub, and (2) eliminate the overwinter survival and recruitment of western mosquitofish while having little effect on least chub recruitment.Location  Bonneville Basin of Utah, USA.Methods  We used short‐term tests in the laboratory at the level of individuals and manipulated temperature (warm, cold and seasonal treatments) in long‐term experiments using mesocosms at the population level.Results  Cold temperatures (≤ 15 °C) reduced the aggression and predation of western mosquitofish on least chub at the level of individuals. At the population level, however, cool summers (≤ 15 °C) eliminated recruitment in both species because they required warm summers (c. 20–30 °C) to survive freezing winters. Although least chub had an overwinter advantage in survival (75% least chub, 45% western mosquitofish), it was overwhelmed by the rapid reproduction of western mosquitofish as temperatures increased in the summer.Main conclusions  Studies at the level of populations are necessary to understand the ultimate effects of introduced species on native taxa. Separation along the temperature niche axis was not sufficient to promote coexistence between these species in habitats with warm summers (c. 30 °C). Although coexistence may be possible in habitats with cool summers (≤ 20 °C) and freezing winters, the ability of niche separation to promote long‐term coexistence between native and introduced species may ultimately depend on their respective rates of evolution. Long‐term coexistence may not be possible if introduced species can adapt to new environmental conditions faster than native species can evolve mechanisms to reduce their harmful effects.