The consumption of psychoactive substances is a feature present in all civilizations. In general, such substances are used in various times and cultures for religious, therapeutic, recreational, and pleasure purposes. Cannabis sativa is an important medicinal plant with long historical use in mankind and also the most widely used drug in the world, ahead of amphetamines, cocaine, and opiates [1].To date, more than 500 compounds have been identified in Cannabis genus, being distributed in 18 chemical classes [2,3]. Among these substances, cannabinoids (also called of terpenophenolics) stand out, due to that they are associated with the pharmacological
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There are several studies investigating the effects of risperidone in autism, but many of these studies are contradictory or inconclusive. This systematic review and meta-analysis investigated the effects of risperidone on five domains of
Aberrant Behaviour Checklist (ABC) scale on Autism Spectrum Disorder (ASD), as well as weight gain and waist circumference. The protocol for the present systematic review and meta-analysis was registered on International Prospective Register of Systematic Reviews (PROSPERO). For this study, we analysed articles (2,459), selecting them according to the PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). Although risperidone is effective for the
treatment of lethargy and inadequate speech, concerns about the association between weight gain, waist circumference and
risperidone require a need to evaluation of the risk-benefit ratio in its use. There was a significant association between
weight gain, waist circumference and risperidone. In Conclusion, it was possible to suggest the efficacy of risperidone for
the treatment of lethargy and inadequate speech. Finally, we emphasize that the risk-benefit in its use should be evaluated.
Protocol number CRD42019122316.
Hibiscus sabdariffa extract (HSE) and Syzygium cumini extract (SCE) have been used in traditional medicine due to their hypoglycemic, antidiabetic, anti-obesity and antioxidant activities. The aim of this study was...
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Cannabis-based products are still not produced in many countries and the great need makes them imported, and often expensive. As an objective, a low-cost extraction method was proposed to facilitate access to the medicinal effects of cannabidiol. The samples of Cannabis sativa used were obtained from in vitro cultivation or from commercially purchased products. Two extraction techniques (ultrasonic extraction and turbo-extraction) and two solvent systems (methanol:chloroform and ethanol) were evaluated. The levels of cannabinoids, total phenolics and total flavonoids were evaluated. The best results were obtained with the turbo-extraction. Ethanol showed a higher yield of cannabinoids, in addition to being a solvent accepted in international conventions in reducing the use of toxic solvents to the environment. Turbo-extraction with ethanol proved to be effective, economical and in line with environmental concerns in the use of ecologically sustainable solvents. As future possibilities, it is proposed to use the information obtained in this study as part of the process of obtaining and subsequent analysis of Cannabis extracts for medicinal purposes.
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