RESUMO BONDER, B. S. A. Composição corporal, status inflamatório e nutricional de cães em pós-cirúrgico alimentados com dieta formulada com altos teores de gordura, proteína e ácidos graxos poli-insaturados ômega-3. [Body composition, inflammatory and nutritional status in post-surgical dogs fed with diet formulated with high levels of fat, protein and omega-3 polyunsaturated fatty acids]. 2017. 81 p.

The post‐operative period can generate immunological stress and can be modulated through supplementation with the omega‐3 series of polyunsaturated fatty acids. This study aimed to evaluate the effects of diets enriched with high doses of eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids and glutamine on inflammatory mediators in dogs before and after ovariohysterectomy (OVH). Twelve female dogs were divided into two groups: group A was fed a commercial diet without the addition of EPA and DHA, and group B was fed an experimental diet enriched with EPA and DHA (0.2 g/100 kcal). Experimental diet intake initiated 21 days before surgery and continued until 30 days after OVH. Parameters measured were serum cytokines (TNF‐α, IL‐6 and IL‐10), C‐reactive protein (CRP), IGF‐1, lymphoproliferation and body composition before and after surgery. Statistical analyses were performed with SAS software considering the effects of age and diet and their interactions, and means were compared by the Tukey test. There was no difference between groups in body weight (p = .682), lean mass (p = .101) and body fat (p = .103). There were no group differences in serum concentrations of TNF‐α, IL‐6, IL‐10, IGF‐1, CRP and the percentage of lymphocyte proliferation. However, a time effect for TNF‐α was observed (p < .001), in which T0P (10 days after the surgical procedure) presented lower values of this cytokine when compared to the other evaluation time points; and interaction effects between group and time were observed for serum concentrations of IL‐6 (p < .001) and IL‐10 (p = .002). OVH procedure was not considered invasive enough to increase inflammatory cytokines after 30 days of surgery, as well as the dosage of the EPA and DHA used before and after the surgery did not modulate the inflammatory markers.

RESUMOA urolitíase é doença frequente que acomete o trato urinário dos animais de companhia. O urólito de estruvita é o tipo mais frequentemente em cães. O objetivo deste trabalho é relatar um caso de dissolução de urólito de estruvita em bexiga urinária por meio de manejo dietético e antibioticoterapia, que apresentou resolução satisfatória. Um cão, fêmea, castrada, de 8 anos, da raça pequinês, foi atendida apresentando sinais clínicos compatíveis com infecção do trato urinário inferior e confirmados na urinálise com a presença de hematúria, piúria e bacteriúria e cultura urinária de 100.000 UFC de Staphylococcus sp. Ao exame radiográfico simples, constatou-se a presença de várias estruturas radiopacas, caracterizando urólitos, sendo a maior medindo 1,26 x 1,63 cm na vesícula urinária. Como tratamento foi instituído antibiotioticoterapia com Cevofecina 8 miligramas por quilograma de peso corporal por via subcutânea a cada 15 dias por 60 dias de acordo com o resultado do antibiograma e, como prescrição nutricional, utilizada dieta comercial seca formulada para dissolução de cálculos de estruvita. O animal foi radiografado no primeiro dia de atendimento, no segundo e no terceiro mês de acompanhamento, verificando-se redução progressiva do tamanho dos urólitos, não havendo evidências radiográficas e sombra acústica ao ultrassom na bexiga urinária após 70 dias de tratamento. A combinação de adequada antibioticoterapia e dieta calculolítica promoveu a dissolução total dos urólitos, não se fazendo necessário intervenção cirúrgica no paciente. SUMMARYUrolithiasis is a frequent disease that affects urinary tract of animals companion. Struvite urolith is the most frequent type in dogs. The aim of this work is to report a dissolution case of struvite urolith in the urinary bladder through management diet and antibiotic therapy, which presented a satisfactory resolution. A female, spayed, eight years old, Pekingese breed dog was attended presenting clinical signs compatible with lower urinary tract infection and confirmed with hematuria, bacteria and urinary bacteria of 100,000 UFC of Staphylococcus sp. At the simple radiographic examination, a new presence of x-rays was detected, characterizing uroliths, being larger measuring 1.26 x 1.63 cm in the urinary vesicle. As a treatment antibiotiotic therapy with Cevofecin 8 milligrams per kilogram of body weight was administered subcutaneously every 15 days for 60 days according to the result of the antibiogram. The nutritional prescription was dry diet formulated for the dissolution of struvite stones. The animal was analyzed on the first day of care, in the second and third months of follow-up, with a progressive reduction in urolith size, no radiological evidence, and acoustic shadow on ultrasound in the urinary bladder after 70 days of treatment. The combination of antibiotic welcome and diet calculator promoted a complete dissolution of the urinary effects, did not become necessary nonpatient surgical intervention.