Camellia sinensis, being belonging Theaceae family, is present more India less than China. A study on Camellia sinensis leaves sample extracted the air-dried leaves powder with different solvents like nhexane, petroleum ether, chloroform (61C), ethanol (78C) and distilled water. Preliminary phytochemical analysis was done measurement of various parameters like extractive value, (moisture content) loss on drying, and quantitative estimation of total ash, and acid insoluble ash, and water-soluble ash value may be helpful for identification of tea leaves powdered drug. The fully grown leaves are bright green colour smooth and leathery, young leaves are pubescent. The estimation of powder microscopy presence in the parenchyma, calcium oxalate, vascular traces, upper epidermis and lower epidermis. These studied recommended that the examined pharmacognostic and phytochemical parameters are of whole great value in quality control, formulation development, and biological activities of camellia sinensis.
Stress is the disturbed homeostatic condition of the organism, and it is represented by non-specific response of the body to any demand imposed on it. Stress brings various changes in physiological condition of the organism, but various mechanism of the body will counteract to maintain homeostasis. Neurotip capsule is effective Ayurvedic treatment for stress related disorders. Neurotip capsules have unique combination of herbs like Jatamansi, Guduchi, Shankapushpi, Ashwagandha, and Probiotics. These herbs are known to sooth the mind, promote calmness and act as a stress buster. In present research study Neurotip formulation was screened for acute toxicity study and sub chronic oral toxicity study on adult albino mice. Animals were observed for behavioural changes, neurological changes and autonomic profile changes. There was no noticeable toxicity and death observed in animals when treated with highest dose of 5000mg/ kg of the formulation. Neurotip was tested on swimming endurance of mice. The results were compared with standard group treated with Geriforte. Test formulation was evaluated by chronic stress model in rats using Omeprazole as standard drug. Assessment of ulcer induction was done to check adaptogenic potential of Neurotip. Ulcer protection by test formulation was found to be 68.44% showing good antistress effects.
Stress is the disturbed homeostatic condition of the organism, and it is represented by non-specific response of the body to any demand imposed on it. Stress brings various changes in physiological condition of the organism, but various mechanism of the body will counteract to maintain homeostasis. In some situations, body’s adaptation to stress is like reward, which is responsible for improvement of body’s performance beyond its capacity. However if organism suffer strong acute or chronic stress, body is unable to maintain homeostasis. Under this condition, various types of diseases and disorders will develop, and even it may lead to death, if it is not managed at proper time. Hazardous stressful situation can be managed by using antistress agent or adaptogen. These agents improve physical and mental working capacity in severe stress circumstances. In different screening models for evaluation of adoptogenic activity, animals are challenged with acute or chronic stress conditions. Various stimulating, stress protective, tonic responses and biochemical markers were measured in evaluation of adoptogenic activity in these animal models.
In this postulations we think about Surface Solid Dispersion and Oro dispersible tablet for upgrade of disintegration rate of valsartan. The medications having low solvency, the disintegration of these medications is rate constraining advance in their bioavailability in oral measurements frames. To defeat this number of innovations are accessible. Among them surface solid dispersion and oro dispersible tablets are two promising systems. Surface solid dispersion is a method for scattering at least one xing on a water solvent transporter of to a great degree high surface territory to accomplish expanded bioavailability and disintegration rates of insoluble medications, and oro dispersible tablets are one of the novel oral medication conveyance framework that break down or scatter rapidly in almost no time after situation in month without water.
Background: Aldol reactions play an important role in the development of organic synthesis-owing to their critical importance for the forming of carbon-carbon bonds while concurrently one or two chiral centers come into being. In the modern scenario, the Aldol condensation reaction has arisen as perhaps the most significant reaction for the formation of novel medicinal agents exhibits promising pharmacological activities. Objective: The purpose of this study is to present newer synthetic approaches through Aldol condensation reaction for the synthesis of diverse scaffolds to explore the promising various types of biological activities. Methods: Aldol condensation concerns the nucleophilic addition reaction of a ketone enolate to an aldehyde to form aldol or β- hydroxy ketone. Occasionally, the aldol addition product losing water molecule yields an α, β-unsaturated ketone. Results: Results showed that amino acids and all lengths of peptides are utilized as chiral catalysts. As of now, the arrangement of catalysts that have been accounted for is intensely one-sided towards proline. This is to some degree because of its exceptional status among the normally happening amino acids as an auxiliary amine and to its restricted underlying adaptability. Conclusion: The present study thus provides useful insight concerning the promising coherent way for the synthesis of prolinamide analogue of proline, through a direct asymmetric aldol condensation reaction. Thus, the current study summarizes various Aldol condensation reactions for the synthesis of novel agents as well as their promising pharmacological importance.
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