ObjectiveTo evaluate the provision of bystander interventions and rates of survival after exercise-related sudden cardiac arrest (SCA).DesignSystematic review.Data sourcesMEDLINE, EMBASE, PubMed, CINAHL, SPORTDiscus, Cochrane Library and grey literature sources were searched from inception to November/December 2020.Study eligibility criteriaObservational studies assessing a population of exercise-related SCA (out-of-hospital cardiac arrests that occurred during exercise or within 1 hour of cessation of activity), where bystander cardiopulmonary resuscitation (CPR) and/or automated external defibrillator (AED) use were reported, and survival outcomes were ascertained.MethodsAmong all included studies, the median (IQR) proportions of bystander CPR and bystander AED use, as well as median (IQR) rate of survival to hospital discharge, were calculated.ResultsA total of 29 studies were included in this review, with a median study duration of 78.7 months and a median sample size of 91. Most exercise-related SCA patients were male (median: 92%, IQR: 86%–96%), middle-aged (median: 51, IQR: 39–56 years), and presented with a shockable arrest rhythm (median: 78%, IQR: 62%–86%). Bystander CPR was initiated in a median of 71% (IQR: 59%–87%) of arrests, whereas bystander AED use occurred in a median of 31% (IQR: 19%–42%) of arrests. Among the 19 studies that reported survival to hospital discharge, the median rate of survival was 32% (IQR: 24%–49%). Studies which evaluated the relationship between bystander interventions and survival outcomes reported that both bystander CPR and AED use were associated with survival after exercise-related SCA.ConclusionExercise-related SCA occurs predominantly in males and presents with a shockable ventricular arrhythmia in most cases, emphasising the importance of rapid access to defibrillation. Further efforts are needed to promote early recognition and a rapid bystander response to exercise-related SCA.
ObjectiveTo evaluate the psychological implications of cardiovascular preparticipation screening (PPS) in athletes.DesignSystematic review.Data sourcesMEDLINE, EMBASE, PubMed, CINAHL, SPORTDiscus, APA PsycInfo, Cochrane Library and grey literature sources.Study eligibility criteriaObservational and experimental studies assessing a population of athletes who participated in a cardiovascular PPS protocol, where psychological outcomes before, during and/or after PPS were reported.MethodsResults of included studies were synthesised by consolidating similar study-reported measures for key psychological outcomes before, during and/or after screening. Summary measures (medians, ranges) were computed across studies for each psychological outcome.ResultsA total of eight studies were included in this review (median sample size: 479). Study cohorts consisted of high school, collegiate, professional and recreational athletes (medians: 59% male, 20.5 years). Most athletes reported positive reactions to screening and would recommend it to others (range 88%–100%, five studies). Increased psychological distress was mainly reported among athletes detected with pathological cardiac conditions and true-positive screening results. In comparison, athletes with false-positive screening results still reported an increased feeling of safety while participating in sport and were satisfied with PPS. A universal conclusion across all studies was that most athletes did not experience psychological distress before, during or after PPS, regardless of the screening modality used or accuracy of results.ConclusionPsychological distress associated with PPS in athletes is rare and limited to athletes with true-positive findings. To mitigate downstream consequences in athletes who experience psychological distress, appropriate interventions and resources should be accessible prior to the screening procedure.PROSPERO registration numberCRD42021272887.
Background and objective Point-of-care focused vascular ultrasound (FOVUS), an assessment of carotid artery plaque, predicts coronary artery disease in outpatients referred for coronary angiography. Our primary objective was to determine the diagnostic accuracy of sonographer-performed FOVUS to predict major adverse cardiac events (MACE) within 30 days among patients with suspected cardiac ischemia in the emergency department (ED). Methods We conducted a prospective cohort study of patients with chest pain presenting to a tertiary care ED who had an electrocardiogram and cardiac troponin testing. The primary outcome was a composite of death, acute myocardial infarction, or re-vascularization at 30 days. A sonographer performed FOVUS scans in consenting eligible subjects. Emergency physicians, blinded to the sonographer FOVUS result, performed a second FOVUS on some subjects. ResultsWe recruited 326 subjects (age 62.1 ± 13.5 years; 166 (52%) men), 319 of whom completed an FOVUS scan by the sonographer. Of these, 198 (62%) had a positive FOVUS scan and 41 (13%) had a 30-day MACE. The sensitivity was 83% (95% CI 71-94%), specificity 41% (95% CI 36-47%), positive-likelihood ratio 1.41 (95% CI 1.19-1.68), and negativelikelihood ratio 0.41 (95% CI 0.23-0.75). Among 71 subjects also scanned by an emergency physician, the Kappa was 0.50 (95% CI 0.31-0.70), suggesting moderate agreement between sonographer and emergency physician on the determination of significant carotid plaque. Conclusions The presence of carotid plaque on sonographer-performed FOVUS is associated with 30-day MACE in ED patients presenting with chest pain. The prognostic performance of FOVUS is not sufficient to support its use as a standalone risk stratification tool in the ED. Future work should investigate FOVUS in conjunction with validated clinical decision rules for chest pain and the impact of enhanced training and quality improvement in the conduct of FOVUS by emergency physicians. Registration This study was registered at clinicaltrials.gov (NCT02947360).
Background Sudden cardiac arrest (SCA) is the leading cause of death amongst athletes and a common cause of death during exercise. Although the provision of cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED) use by bystanders improves outcomes after SCA, the impact of these interventions within exertional settings requires further investigation. Purpose The purpose of this systematic review was to evaluate the role of bystander CPR and AED use on survival after exercise-related SCA. Methods Literature searches in MEDLINE, EMBASE, PubMed, CINAHL, SPORTDiscus, and Cochrane Library were queried from inception until November 2020 using a comprehensive search strategy. Grey literature searches of Google Scholar and CADTH Grey Matters were also performed. Abstract screening, full-text review, and data extraction of eligible studies was conducted independently by two reviewers, with any conflicts discussed until consensus reached. Eligible studies included observational research studies assessing a population of exercise-related SCAs (defined as an out-of-hospital cardiac arrest which occurred during exercise or within 1-hour of cessation of activity), where the rate of bystander CPR and/or AED use was provided, and survival outcomes were reported. Abstracts, studies with overlapping patient data, and/or studies of n≤10 were excluded. Among studies with similar populations, the overall rates (median, range) of bystander CPR, AED use, and survival outcomes were calculated. Results A total of 3,718 records were identified from literature searches, and after removal of duplicates, 2,850 were screened. Among those screened, 176 articles were selected for full-text review, of which 29 studies were included in this review. Majority of included studies were cohort studies (2 case series and 2 cross-sectional), with a median sample size of 91. Most patients who suffered from an exercise-related SCA were male, middle-aged, and presented with a shockable arrest rhythm. The median rate of bystander CPR reported amongst 22 studies was 71% (31%-100%), whereas the median rate of bystander AED use reported amongst 16 studies was 31% (2%-100%) (Table). Among the 19 studies which reported the rate of survival to hospital discharge, survival ranged from 11% to 77%, with a median rate of 32% (Table). Patients who survived to hospital discharge more frequently received bystander CPR and had an AED applied than patients who died (Figure). Conclusions Survival rates after exercise-related SCA were higher than previously reported in other settings not related to exercise. These outcomes are likely related to a higher rate of bystander interventions in exertional or sport-specific settings. The findings of this review encourage layperson education in basic life support, the availability of AEDs in exercise facilities, and the development of emergency action plans to provide point-of-performance cardiac care in exertional settings. Funding Acknowledgement Type of funding sources: None.
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