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Performance of integrated production scheduling and advanced process control with disturbances is summarized and reviewed with four progressive stages of scheduling and control integration and responsiveness to disturbances: open-loop segregated scheduling and control, closed-loop segregated scheduling and control, open-loop scheduling with consideration of process dynamics, and closed-loop integrated scheduling and control responsive to process disturbances and market fluctuations. Progressive economic benefit from dynamic rescheduling and integrating scheduling and control is shown on a continuously stirred tank reactor (CSTR) benchmark application in closed-loop simulations over 24 h. A fixed horizon integrated scheduling and control formulation for multi-product, continuous chemical processes is utilized, in which nonlinear model predictive control (NMPC) and continuous-time scheduling are combined.

This study examines to what extent study design decisions influence the perceived efficacy of consensus messaging, using medicinal cannabis as the context. We find that researchers’ decisions about study design matter. A modified Solomon Group Design was used in which participants were either assigned to a group that had a pretest (within-subjects design) or a posttest only group (between-subjects design). Furthermore, participants were exposed to one of three messages—one of two consensus messages or a control message—attributed to the National Academies of Sciences, Engineering and Medicine. A consensus message describing a percent (97%) of agreeing scientists was more effective at shifting public attitudes than a consensus message citing substantial evidence, but this was only true in the between-subject comparisons. Participants tested before and after exposure to a message demonstrated pre-sensitization effects that undermined the goals of the messages. Our results identify these nuances to the effectiveness of scientific consensus messaging, while serving to reinforce the importance of study design.

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