Efficient and reliable tools that help us to manage and plan our daily activities are an essential part of our busy life. Trip planner is one of the tools that not only helps to plan an unfamiliar journey but also is important for reliable planning of the dynamic daily travel. Numerous trip planners from bike apps to sophisticated airline based intercontinental travel are developed and implemented. Availability of a Btruly intermodal^trip planner with real time information is the need of the hour, and is something which is currently not Btrulyâ vailable. This paper presents the key architecture requirements for the development of the intermodal trip planners. It also discuss about the challenges in the development and implementation of a truly multimodal trip planner.
An Emergency Use Authorization (EUA) was issued by the FDA on December 22, 2021 for the investigational antiviral drug nirmatrelvir copackaged with the HIV-1 protease inhibitor ritonavir (Paxlovid -Pfizer) for outpatient treatment of mild to moderate COVID-19 in children 12 years and old that are high risk of severe disease. Due to the effects, Paxlovid has on liver metabolism it has a copious amount of drug-to-drug interactions. Here we present a rare case of a patient that was given Paxlovid and continued to take her Ranolazine at home. She presented to the emergency department obtunded and after an initial workup, it was determined to be secondary to ranolazine toxicity. She eventually recovered over 54 hours and returned to her baseline.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.