Ultraviolet radiation (UVR) which could induce skin damage and skin disease is a growing concern due to the increase in global warming. Brown macroalgae Sargassum cristaefolium has been recognized to exhibit UV protective activities. However, the mechanism of its photoprotective activity remains unclear. The purpose of this study is to investigate the potential mechanism of S. cristaefolium’s photoprotective activity against UV radiation. Phytochemical analyses revealed valuable bioactive compounds in SCE, such as fucoxanthin which is widely known as an anti-inflammatory carotenoid. Treatment with SCE before UV-A radiation show reduced levels of wrinkles and desquamation. Interestingly, SCE treatment induces the skin healing process after UV radiation. SCE effectively inhibited proinflammatory TNF-α and IL-6 expression while increasing IL-10 production in the BALB/c mice skin. Current results suggest that SCE potentially protects the skin by attenuation of inflammatory cytokines. In addition, SCE demonstrates promising antibacterial activity (MIC = 1.302 µg/mL) against Staphylococcus aureus. Overall, SCE could be a source of an effective anti-inflammatory agent protecting against UV irradiation-induced skin damages.
Exessive use of inorganic fertilizers in rice production systems, causes various negative effects in the environemnt, such as reducing soil fertility and increases pollution, which disturbs agricultural sustainability. Understanding raw materials for developing organic fertilizers which are cheap and adaptive to our environment, is an important study recently. Many researchers reported that brown algae could increase growth and yield of several species of plants. This due to brown algae extract contain plant growth hormone and essential elements to stimulate growth and production of plants. This article report growth and yield of rice plants suplied with mixtured extract of brown algae. Several species of brown algae were collected in coastal beach of Lombok. The seaweeds were cutted into small peaces, extracted with boiled water for 30 minute and filtered using filter whatman no.1 to get solid and liquid extract. Mixtured solid extracts were added in soil media. On the other hand, the mixtured liquid extracts were sprayed to rice plants during vegetative growth. The results shown that mixtured solid extracts increased growth and yield of rice plants. However, mixtured liquid extract did not stimulate growth and yield of rice plants. This suggests that brown algae is a potential raw material for development of organic fertilizers, which are adaptive to environment to support sustainable agriculture.
Seagrass is a water plant that has flowers and ability to adapt to live and grow in the sea like a terrestrial plant. The survival of seagrass is greatly influenced by physical and chemical parameters of waters, such as pH, temperature, and salinity. The Intergovernmental Panel on Climate Change (IPCC) report by the end of 21st century, CO2 in the atmosphere has doubled along with the industrial development. The increase in CO2 in the atmosphere causes ocean acidification, it can change the chemical structure and decrease the pH of sea water. The low pH of sea water influences plant phisiology such as the inhibition of photosynthesis and growth. The purpose of this study is to examine the effect of pH on the growth and photosynthesis rate of seagrass Thalassia hemprichii. The study used Completely Randomized Design with 3 treatments control (8.10-8.50), medium pH (7.76-8.00) and low pH (7.50-7.75) in 5 replicates. The results showed that growth rate, photosynthetic rate and chlorophyll content has a bigger value on control treatment than the low pH treatment. The ANOVA test results were not significant for all treatment variables and had a negative impact on the survival of seagrass.
The demand for agricultural commodities increases from year to year, so farmers also have to increase the production of agricultural products. Farmers can increase agricultural yields through the excessive use of inorganic fertilizers. This causes many problems for the environment, so it is required to reduce the use of inorganic fertilizers in agricultural land. This study aimed to determine the effect of a combination of organic and inorganic fertilizers on the growth and yield of rice. This research was carried out in a screen house in Jatisela, Gunung Sari Subdistrict, Lombok from June to October 2020. The three treatments used in this study were P0 N0 with no organic and inorganic fertilizers; P0 N100 with a dose of 100% inorganic fertilizer and P50 N50 with a dose of 50% organic fertilizer and 50% inorganic fertilizer. The results showed that the combination of organic fertilizers (50%) and inorganic fertilizers (50%) can increase the growth and yield of rice in the screen house compared to control plants and plants which given only 100% inorganic fertilizers. In summary, the combination of organic and inorganic fertilizers can reduce the use of inorganic fertilizers.
The red macroalga Gelidium latifolium is widely distributed in the coastal areas of Indonesia. However, current knowledge on its potential biological activities is still limited. In this study, we investigated the potential bioactive compounds in Gelidium latifolium ethanol extract (GLE), and its cytotoxic effects against the murine B16-F10 melanoma cell line. GLE shows high total phenolic content (107.06 ± 17.42 mg GAE/g) and total flavonoid content (151.77 ± 3.45 mg QE/g), which potentially contribute to its potential antioxidant activity (DPPH = 650.42 ± 2.01 µg/mL; ABTS = 557.01 ± 1.94 µg/mL). ESI-HR-TOF-MS analysis revealed large absorption in the [M-H]- of 327.2339 m/z, corresponding to the monoisotopic molecular mass of brassicolene. The presence of this compound potentially contributes to GLE’s cytotoxic activity (IC50 = 84.29 ± 1.93 µg/mL). Furthermore, GLE significantly increased the number of apoptotic cells (66.83 ± 3.06%) compared to controls (18.83 ± 3.76%). Apoptosis was also confirmed by changes in the expression levels of apoptosis-related genes (i.e., p53, Bax, Bak, and Bcl2). Downregulated expression of Bcl2 indicates an intrinsic apoptotic pathway. Current results suggest that components of Gelidium latifolium should be further investigated as possible sources of novel antitumor drugs.
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