Background-Healthful dietary patterns, including eating fruits and vegetables (F&V) and avoiding obesity may decrease the risk of cancer and other chronic diseases. In addition to promoting health for the general population, a cancer diagnosis may provide a "teachable moment," facilitating the adoption of more healthful eating habits and leading to lower risk of chronic disease and better overall health.
Background: Prostate cancer affects one of six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies. Methods: We undertook a multisite, randomized controlled trial to test the effects of low-fat and/or flaxseedsupplemented diets on the biology of the prostate and other biomarkers. Prostate cancer patients (n = 161) scheduled at least 21 days before prostatectomy were randomly assigned to one of the following arms: (a) control (usual diet), (b) flaxseed-supplemented diet (30 g/d), (c) low-fat diet (<20% total energy), or (d) flaxseed-supplemented, low-fat diet. Blood was drawn at baseline and before surgery and analyzed for prostate-specific antigen, sex hormone-binding globulin, testosterone, insulin-like growth factor-I and binding protein-3, C-reactive protein, and total and
Protein-energy undernutrition has its most devastating consequences during growth. Postal somatic growth now appears to be regulated in large part by the somatomedins, a family of growth hormone-dependent peptide mitogens. This study, using growing rats as the model, was designed to determine the relationship between protein and energy intake and serum immunoreactive somatomedin-C. Four-week-old male Sprague-Dawley rats were fed ad libitum three levels of isoenergetic protein diets (5%, 10%, and 15% lactalbumin) at each of three levels of energy (ad libitum, 75% or 50% of ad libitum quantities). Dietary fat was held constant at 11.9% as cottonseed oil. At 5 weeks of age, serum somatomedin-C concentration was predominately influenced by the dietary protein and increased linearly as protein intake increased from 5% to 15%. at 6, 9, and 12 weeks of age, serum somatomedin-C concentration was influenced by both protein and energy intake, although protein intake appeared to be the more important variable. Serum somatomedin-C was highly correlated with both body weight (r = 0.84, P less than 0.001) and tail length (r = 0.74, P less than 0.01). These results indicate that measurement of immunoreactive somatomedin-C provides a valuable biochemical index of protein-energy nutriture.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.