A series of stable
polysaccharide derivatives that spontaneously
self-assemble into nanocarriers was synthesized by applying a reductive
amination on chitosan. The prepared nanocarriers were comprehensively
studied and found to allow encapsulation of molecular cargo in both
aqueous and lipidic media and deliver this cargo across biological
barriers. The nanocarriers have demonstrated effective transdermal
delivery of diclofenac (Voltaren), a nonsteroidal anti-inflammatory
drug, by increasing its skin permeation up to 100 vs the tested control.
The modified polysaccharides were studied with a panel of three types
of bioreporter bacteria sensitive to genotoxic and cytotoxic stresses.
These studies showed the general safety of the prepared nanocarriers
and provided insights concerning their activity in collaboration with
the aliphatic side chain length. The described nanocarriers could
be applied as tunable biocompatible vehicles for the delivery of medicines,
cosmetic agents, and in other applications.
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