Background: The Coronavirus disease (COVID-19) pandemic as a large scale stressor could have negative effects on the mental health of medical students. Since gender differences in mental health may exist, it is important to see if a large scale stressor like the pandemic may be associated with variances in the psychological distress between both genders. Objectives: To assess and compare the psychological distress of male and female medical students during the COVID-19 pandemic. Methods: A cross-sectional survey was carried out among 1010 medical students from three universities in southwestern Nigeria within the first six months of the first reported case of the COVID-19 pandemic. The respondents were purposively selected. Data was obtained online on participants’ demographic and psychological distress using the General Health Questionnaire 12 (GHQ-12). Data was analyzed using the SPSS version 21, student t and chi-square tests were used to assess gender differences, and multivariate regression to assess the predictors of psychological distress among both genders. p values less than 0.05were considered statistically significant. Results: Overall, female participants (OR=1.455, 95% CI= 1.095-1.936) were twice more likely to have experienced psychological distress than males during the COVID-19 pandemic. Age (OR=0.922, 95% CI= 0.867-0.979), being in pre-clinical years (OR= 1.394, 95% CI= 1.004-1.938), having a family income less than 100,000 naira (OR= 1.379, 95% CI=1.442-6.723) a previous history of mental illness (OR=3.077, 95% CI= 1.430-6.615) and having a relative/acquaintance diagnosed with COVID 19(OR=1.646, 95% CI= 1.062-2.551) were independently associated with psychological distress among the respondents. When comparing both genders,among females, age (OR=0.886, 95% CI= 0.803-0.978), family income less than 100,000 naira (OR=1.898, 95% CI= 1.306-2.759) and a previous history of mental illness (OR=5.266, 95% CI= 1.894-14.635) were associated with psychological distress, while, being in pre-clinical years (OR= 1.713, 95% CI= 1.052-2.790) was associated with psychological distress among males. Conclusion: Females had more psychological distress compared to male students. It is recommended that gender-specific interventions addressing psychological distress among medical students are instituted. Keywords: Psychological distress; psychological impact; gender; COVID-19; medical students.

BackgroundThe Coronavirus disease (COVID-19) pandemic as a large scale stressor could have negative distress on the mental health on medical students. Since gender differences in mental health may exist between males and females, it would prove interesting to see if a large scale stressor such as the pandemic will cause variances in the psychological distress between both genders.This study assessed and compared the psychological distress of COVID-19 among male and female medical students in medical schools in South-Western NigeriaMaterials and methodsA cross-sectional online survey using was carried out among 1010 medical students from three largest universities in south western Nigeria during the COVID-19 pandemic. The respondents were purposively selected, data was obtained on participants demographic and psychological distress was assessed using the General Health Questionnaire 12 (GHQ-12). Data was analyzed using the SPSS version 21 statistical software, chi square was used to assess gender differences, multivariate regression analysis assessed the predictors of psychological distress among both gendersand p values less than 0.05 were considered significant.ResultsFemale medical students are at a higher risk of psychological distress compared to their male counterparts (p<0.005). Females were almost twice at risk of psychological distress during the COVID-19 pandemic than males (OR=1.534, 95% p=0.003). Females with a positive history of mental illness were five times more at risk of psychological distress during the COVID-19 pandemic compared to females with no previous mental health history (OR=5.102, p=0.002)ConclusionFemales were at higher risk of psychological distress compared to male students. Gender specific interventions addressing psychological distress among medical students are recommended.

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