BACKGROUND: The COVID-19 pandemic caused deaths and severe clinical complications associated with thrombosis and hypercoagulability, motivating this literature review. OBJECTIVE: To analyze the scope of scientific publications that demonstrate an association of thromboembolism with complications of COVID-19. METHOD: A systematic literature review was performed to identify clinical complications associated with thrombosis in people exposed to SARS-CoV-2 infection. The articles were selected from MEDLINE database after being screened and filtered to extract the methodologies used and the evidence of clinical complications by compromised organs or systems and pathology description. The evidence was extracted in Cohort Studies for statistical analysis and hypothesis testing (t-test). RESULTS: A total of 208 studies were selected. Observational Studies were predominant, corresponding to 64% of the total, and other methodologies corresponded to 9% in the inclusion. Review articles were excluded and corresponded to the remaining 27% of the selected articles. Subsequently, 150 articles were screened, and 121 were filtered. Among these, 11 Cohort Studies were extracted as the sample, which were eligible for analysis and subsequent Hypothesis Test. This test showed a Mean Difference of 4.74 [Ha (μ=8.08 Exposure) > (μ=3.33 No exposure)], with a p-value of 0.096 for a 95% confidence interval. Despite the numerical value of the difference in the means due to the influence of variance, the test result was not statistically significant due to the small number of the sample of Cohort studies. CONCLUSION: It was observed that prothrombotic conditions were present and translated by hypercoagulability in the evaluated articles. Individuals exposed to SARS-CoV-2 infection have been shown to experience complications caused by thrombosis more often than the unexposed. It is suggested to conduct a Meta-analysis with a larger sample of Cohort Studies to further analyze this association.
Essa pesquisa teve como objetivo geral analisar a associação entre os níveis séricos das adipocinas leptina e adiponectina e da grelina com a fissura e abstinência em tabagistas. O método adotado foi uma pesquisa de abordagem quantitativa, tendo como campo o CIPIT/HU–UFJF. Foram analisadas as concentrações séricas das adipocinas adiponectina e leptina e da grelina correlacionando com o status tabágico no início de tratamento e quatro meses após. Os dados foram testados quanto à normalidade e, após, aplicados testes, usando o SPSS. Os resultados apontaram que não houve significância nos dados antropométricos, nos níveis séricos de adiponectina ajustada ao IMC e de grelina. Já os níveis séricos de leptina ajustados para circunferência de cintura tiveram significância. Quanto ao nível sérico de adiponectinas, estava elevado no início do tratamento naqueles que pararam de fumar. De acordo com o QSU houve redução do consumo em todos os participantes, caracterizando redução de danos com o tratamento. Conclui-se que as adipocinas podem ser consideradas, não somente marcadores para fissura e risco de recaída, mas também preditores para o sucesso do tratamento de tabagistas; a leptina como marcador para fissura e risco de recaída e; a adiponectina como marcador e preditor para cessação tabágica, contribuirá significativamente para o sucesso do tratamento de tabagistas.
Objective: Scope review of the literature to assess the involvement of organs and systems and the existence of an association of prothrombotic factors with the complications of individuals infected with the SARS-CoV-2 virus.Introduction: The COVID-19 Syndrome in individuals who develop thromboembolic complications motivates this study. Understanding the phenotypic expression of these complications is motivating. The unknown cause-and-effect relationship of complications encourages the search for clarification through this literature scope review, hoping to find indicators of association between thromboembolic phenomena and complications in individuals infected with SARS-CoV-2.Inclusion criteria: Primary studies on complications of COVID-19 associated with thrombosis, published as of January 2020 in English, will be the primary focus. I am expressing impairment of organs and systems by clinical complications of those infected with SARS-CoV-2.Methods: The proposed scope review will be guided by the J.B.I. (Joana Brigs Institute) Methodology and PRISMA-ScR protocol. The database will be MEDLINE via PubMed, and the population of selected articles will be divided into 3 phases (screening, filtering, and sampling) of data extraction and stored in sequenced worksheets with sorted data. Electronic tools will contribute to referencing sources (Software_EndNote), data selection (Software_Rayyan), classification, and database (Software_Excel). The results presented by diagrams should demonstrate the primary methodologies used in the studies under analysis, the clinical complications of COVID, and evidence on risk factors from the cohort studies.
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