Evidence of prothrombotic factors associated with COVID-19 complications: a scoping review protocol

Abstract

Objective: Scope review of the literature to assess the involvement of organs and systems and the existence of an association of prothrombotic factors with the complications of individuals infected with the SARS-CoV-2 virus.Introduction: The COVID-19 Syndrome in individuals who develop thromboembolic complications motivates this study. Understanding the phenotypic expression of these complications is motivating. The unknown cause-and-effect relationship of complications encourages the search for clarification through this literature scope review, hoping to find indicators of association between thromboembolic phenomena and complications in individuals infected with SARS-CoV-2.Inclusion criteria: Primary studies on complications of COVID-19 associated with thrombosis, published as of January 2020 in English, will be the primary focus. I am expressing impairment of organs and systems by clinical complications of those infected with SARS-CoV-2.Methods: The proposed scope review will be guided by the J.B.I. (Joana Brigs Institute) Methodology and PRISMA-ScR protocol. The database will be MEDLINE via PubMed, and the population of selected articles will be divided into 3 phases (screening, filtering, and sampling) of data extraction and stored in sequenced worksheets with sorted data. Electronic tools will contribute to referencing sources (Software_EndNote), data selection (Software_Rayyan), classification, and database (Software_Excel). The results presented by diagrams should demonstrate the primary methodologies used in the studies under analysis, the clinical complications of COVID, and evidence on risk factors from the cohort studies.